Postdoctoral Fellow- WNT/R-spondin signaling

Staff Name: 
Andres M. Lebensohn, Ph.D.
Laboratory of Cellular and Molecular Biology
Research Area Keywords: 

WNT/R-spondin signaling, embryonic development

Position Description: 

We seek highly motivated Postdoctoral Fellows interested in developing independent research projects in the area of cell signaling at the interface of development, stem cells and cancer. Candidates will join the group of Dr. Andres Lebensohn, an Earl Stadtman Principal Investigator in the Laboratory of Cellular and Molecular Biology (LCMB) at the Center for Cancer Research (CCR) of the National Cancer Institute (NCI), NIH. We combine functional genomics and CRISPR genome editing with cell biology and biochemistry to study how signaling pathways are used, reused and repurposed to drive the myriad different cellular processes that give rise to tissues and organs during embryonic development, and maintain them in adult life. A major focus of the lab is on WNT signaling, a fundamental pathway that orchestrates embryonic patterning, morphogenesis, and promotes stem cell self-renewal and tissue regeneration. We use powerful genetic screens in human cells to discover new regulatory mechanisms. We probe their molecular underpinning through biochemistry and cell biology. We seek to unravel how they generate distinct physiological outcomes using organoid cultures and animal models. Based on this understanding, we strive to devise more selective therapeutic strategies to target tumors driven by dysregulation of WNT signaling. Descriptions of specific research projects can be found at

CCR is working to solve the most pressing problems in the field through basic, translational and clinical cancer research to create the cancer medicines of tomorrow and is dedicated to preparing the next generation of cancer researchers. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

The NCI CCR is dedicated to preparing the next generation of cancer researchers and offers a training environment that is second-to-none in quality of science and mentoring by outstanding principal investigators, including nine members of the National Academy of Science and eight members of the National Academy of Medicine. CCR offers fellows access to cutting-edge technologies and cores, a highly collaborative environment, awards and research forums to recognize outstanding post docs, continuous scientific symposia and lectures featuring leading researchers, a strong commitment to translational research, and a vibrant clinical research program housed in the world’s largest dedicated research hospital, the NIH Clinical Center.

Multiple Positions Available: 
C.V. Required: 
Number of References Required: 
Experience Required: 

Candidates must have completed a Ph.D. within the past 3 years. At least one first/co-first authored manuscript (published or submitted) is highly recommended. Candidates with backgrounds in cell, stem cell, developmental or cancer biology are encouraged to apply. Experience in small-molecule screening, biochemistry, cell biology, organoid tissue culture or mouse genetics is welcome but not required. Fellows will have exceptional stipend support for the entire duration of their post-doc, funds for travel to scientific conferences, and full healthcare benefits.

Additional Information: 

Bethesda is located adjacent to Washington, D.C. and is an urban core of Montgomery County, MD. Bethesda is one of the most affluent and highly educated communities in the United States. It is a vibrant town, and a destination for shopping, dining and artistic and cultural events.

How To Apply: 

Please send the following information to 1) a cover letter describing A) previous research accomplishments clearly stating the key findings and significance of your work, and B) future interests explicitly stating why you are interested in my research and which projects inspire you; 2) a CV including bibliography and contact information for three references. Please use the following email subject: “Application for postdoctoral position”.

Contact Name: 
Andres Lebensohn
Contact E-mail: 
Contact Phone: 

HHS, NIH, and NCI are Equal Opportunity Employers