Postdoctoral Fellow - WNT signaling in cancer

Staff Name: 
Andres M. Lebensohn, Ph.D.
Lab/Branch/Program: 
Laboratory of Cellular and Molecular Biology
Location: 
Bethesda
Research Area Keywords: 

WNT signaling, development, stem cells, cancer

Position Description: 

We seek a highly motivated Postdoctoral Fellow interested in developing independent research projects in the area of cell signaling at the interface of development, stem cells and cancer. The candidate will join the group of Dr. Andres Lebensohn, an Earl Stadtman Principal Investigator in the Laboratory of Cellular and Molecular Biology (LCMB) at the Center for Cancer Research (CCR) of the National Cancer Institute (NCI). We combine functional genomics with cell biology and biochemistry to study how signaling pathways are used, reused and repurposed to drive the myriad different cellular processes that give rise to tissues and organs during embryonic development and maintain them in adult life. A major focus of the lab is on WNT signaling, a fundamental pathway that orchestrates embryonic patterning and morphogenesis, and promotes stem cell self-renewal and tissue regeneration. We use powerful genetic screens in human cells to discover new regulatory mechanisms. We probe their molecular underpinning through biochemistry and cell biology. We seek to unravel how they generate distinct physiological outcomes using organoid cultures and animal models. Based on this understanding, we strive to devise more selective therapeutic strategies to target tumors driven by dysregulation of WNT signaling. Descriptions of specific research projects can be found at https://ccr.cancer.gov/Laboratory-of-Cellular-and-Molecular-Biology/andres-m-lebensohn. Fellows have exceptional stipend support for the entire duration of their post-doc, full healthcare benefits and funds for travel to scientific conferences. The open lab space, collegial atmosphere and joint weekly seminars shared by the seven research groups of the LCMB (https://ccr.cancer.gov/Laboratory-of-Cellular-and-Molecular-Biology) give Fellows a strong support network and plenty of opportunities to present and discuss their research with close peers.

CCR is working to solve the most pressing problems in the field through basic, translational and clinical cancer research to create the cancer medicines of tomorrow and is dedicated to preparing the next generation of cancer researchers. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

CCR is dedicated to preparing the next generation of cancer researchers and offers a training environment that is second-to-none in quality of science and mentoring by outstanding principal investigators, including nine members of the National Academy of Science and eight members of the National Academy of Medicine. CCR offers fellows access to cutting-edge technologies and cores, a highly collaborative environment, awards and research forums to recognize outstanding post docs, continuous scientific symposia and lectures featuring leading researchers, a strong commitment to translational research, and a vibrant clinical research program housed in the world’s largest dedicated research hospital, the NIH Clinical Center.

Number of Positions: 
1
C.V. Required: 
Yes
Number of References Required: 
3
Experience Required: 

Candidates must have completed a Ph.D. within the past 3 years. At least one first/co-first authored manuscript (published or submitted) is highly recommended. Candidates with backgrounds in cell, stem cell, developmental or cancer biology are encouraged to apply. Experience in small-molecule screening, biochemistry, cell biology, organoid tissue culture or mouse genetics is welcome but not required.

Additional Information: 

Bethesda, located adjacent to Washington, D.C., is an urban core of Montgomery County, MD. Bethesda is one of the most affluent and highly educated communities in the United States. Living in Bethesda offers residents a suburban feel with a lot of restaurants, coffee shops, and parks. A short metro ride to Washington D.C. and the surrounding areas provides Fellows and their families access to numerous free museums and activities (https://washington.org/free-things-to-do).

How To Apply: 

Please send the following information to andres.lebensohn@nih.gov:

1) a cover letter describing A) previous research accomplishments, clearly stating the key findings and significance of your work and B) future interests, explicitly stating why you are interested in my research and which projects inspire you.

2) a CV including bibliography and contact information for three references.

Please use the following email subject: “Application for postdoctoral fellow position”

Contact Name: 
Andres Lebensohn
Contact E-mail: 

HHS, NIH, and NCI are Equal Opportunity Employers