Postdoctoral Fellow - Tumor Immunology
The successful applicant will join a team studying CD4+ T cell responses to cancer, building on recent work in the laboratory (Ciucci et al, 2019, Immunity; Magen et al., submitted, references below). Experimental approaches leverage in vitro T cell Crispr mutagenesis and adoptive transfers, and analyses of experimental tumors using a variety of techniques, including flow cytometry, population and single-cell RNA sequencing and ATAC sequencing. Collaborative computational biology support is provided for these approaches, but bioinformatics training opportunities will be provided if interest.
Applicants should have (or be within a few months of obtaining) an MD or PhD in immunology, biochemistry, genetics or a similar field, with no more than 5 years of post-doctoral experience. Candidates associating a strong publication record with experience in mouse models, flow cytometry, bioinformatics, or gene expression analyses will be preferred.
The laboratory is located on the main NIH campus in Bethesda. We have access to an exceptional set of research facilities, including flow cytometry, imaging, next generation sequencing, mouse mutagenesis (transgenesis, homologous recombination and Crispr genome editing), and have collaborations and regular meetings with multiple NIH and academic groups. Recent relevant work includes:
- Ciucci T, Vacchio MS, Gao Y, Tomassoni Ardori F, Candia J, Mehta M, Zhao Y,Tran B, Pepper M, Tessarollo L, McGavern DB, Bosselut R. The Emergence and Functional Fitness of Memory CD4(+) T Cells Require the Transcription Factor Thpok. Immunity. 2019 Jan 15;50(1):91-105.e4.
- Magen A, Nie J, Ciucci T, Tamoutounour S, Zhao Y, Mehta M, Tran B, McGavern DB, Hannenhalli S, Bosselut R. Single-cell profiling of tumor-reactive CD4+ T-cells reveals unexpected transcriptomic diversity. doi: https://doi.org/10.1101/543199 (biorxiv pre-print).
- Carpenter AC, Wohlfert E, Chopp LB, Vacchio MS, Nie J, Zhao Y, Shetty J, Xiao Q, Deng C, Tran B, Cam M, Gaida MM, Belkaid Y, Bosselut R. Control of Regulatory T Cell Differentiation by the Transcription Factors Thpok and LRF. J Immunol.2017 Sep 1;199(5):1716-1728.
More information at https://ccr.cancer.gov/Laboratory-of-Immune-Cell-Biology/remy-bosselut.
Interested candidates should submit a CV, including a list of publications, and the name of three references to Remy Bosselut at email@example.com
HHS, NIH, and NCI are Equal Opportunity Employers