Postdoctoral Fellow - systems biology, microscopy

Staff Name: 
Steven D. Cappell, Ph.D.
Laboratory of Cancer Biology and Genetics
Research Area Keywords: 

systems biology, microscopy, cell cycle

Position Description: 

A postdoctoral position is available in the lab of Dr. Steven Cappell in the Laboratory of Cancer Biology and Genetics, Center for Cancer Research (CCR), National Cancer Institute (NCI). Dr. Cappell is interested in understanding how signal transduction networks are wired to form logical circuits and to understand how these networks function in space and time to regulate diverse aspects of human physiology. Our approach is to combine live-cell imaging of fluorescent biosensors in single cells with genetic and pharmacological perturbations to identify regulatory mechanisms of signal transduction pathways. In particular, we are interested in understanding how cells make the decision to enter the cell cycle and proliferate and how this decision is perturbed in cancer.

The postdoctoral fellow will investigate cell cycle dynamics in both normal and cancer cells using cutting-edge imaging and analysis tools. An additional goal of this project will be to combine live-cell imaging pipelines with single-cell RNA sequencing.

CCR is working to solve the most pressing problems in the field through basic, translational and clinical cancer research to create the cancer medicines of tomorrow and is dedicated to preparing the next generation of cancer researchers. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

The NCI CCR is dedicated to preparing the next generation of cancer researchers and offers a training environment that is second-to-none in quality of science and mentoring by outstanding principal investigators, including nine members of the National Academy of Science and eight members of the National Academy of Medicine. CCR offers fellows access to cutting-edge technologies and cores, a highly collaborative environment, awards and research forums to recognize outstanding post docs, continuous scientific symposia and lectures featuring leading researchers, a strong commitment to translational research, and a vibrant clinical research program housed in the world’s largest dedicated research hospital, the NIH Clinical Center. ​

Number of Positions: 
C.V. Required: 
Number of References Required: 
Experience Required: 

We seek a talented, curious, and highly motivated postdoctoral fellow with an interest in cell biology, genomics, signal transduction, or live-cell imaging. Ability to implement customized algorithms (MATLAB, R, python, etc.) is highly desirable. Applicants should have a Ph.D. (or expected to receive a Ph.D.) or M.D. equivalent at the time of joining the lab. This position is subject to a background investigation. For additional information on the Cappell Lab, please visit:

Additional Information: 

Bethesda, located adjacent to Washington, D.C., is an urban core of Montgomery County, MD. Bethesda is one of the most affluent and highly educated communities in the United States. Living in Bethesda offers residents a suburban feel with a lot of restaurants, coffee shops, and parks. The public schools in Bethesda are highly rated.

How To Apply: 

To apply, please send a cover letter describing your interest in our lab, a CV with bibliography, and contact information for 3 references to Dr. Steven Cappell (

Contact Name: 
Steven Cappell
Contact E-mail: 

HHS, NIH, and NCI are Equal Opportunity Employers