Postdoctoral Fellow - nucleosomal remodeling, DNA methylation
nucleosomal remodeling, DNA methylation, histone modif
The Epigenetics Section of the Mouse Cancer Genetics Program, headed by Dr. Kathrin Muegge, has an open post-doctoral position. Our section studies the causes and consequences of the ICF4 syndrome, a complex disease with symptoms of immunodeficiency, genomic instability, mental retardation and compromised germ cell development. Genetic mutations of Lsh/HELLS, a chromatin remodeling protein, can cause the ICF4 syndrome. Lsh modulates genome-wide chromatin accessibility, influences DNA methylation levels and alters retrotransposon expression. Using mouse models with tissue-specific deletions of Lsh, we are using a variety of molecular and cell biologic techniques to determine chromatin states in affected tissues during development. Uncovering molecular pathways will deepen our understanding of the pathophysiology underlying this disease and should help to identify novel molecular targets for therapeutic intervention.
The Center for Cancer Research (CCR) is working to solve the most pressing problems in the field through basic, translational and clinical cancer research to create the cancer medicines of tomorrow and is dedicated to preparing the next generation of cancer researchers. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
The NCI CCR is dedicated to preparing the next generation of cancer researchers and offers a training environment that is second-to-none in quality of science and mentoring by outstanding principal investigators, including nine members of the National Academy of Science and eight members of the National Academy of Medicine. CCR offers fellows access to cutting-edge technologies and cores, a highly collaborative environment, awards and research forums to recognize outstanding post docs, continuous scientific symposia and lectures featuring leading researchers, a strong commitment to translational research, and a vibrant clinical research program housed in the world’s largest dedicated research hospital, the NIH Clinical Center.
Applicants must have a Ph.D. degree and expertise in molecular biology, genetics, biochemistry, and cell biology. We are looking for a candidate who possesses an exceptional motivation for academic research and less than 1 year postdoctoral experience. Those with experience in germ cell development, neurobiology and epigenetics are particularly encouraged to apply. Good oral and written communication skills are required.
This position is located at CCR’s campus in Frederick, Maryland. Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views, wineries, orchards, and a vibrant Main Street community. It is less than an hour’s drive from the NIH main campus as well as the Appalachian Trail, Washington, D.C., Baltimore, and Gettysburg. The city offers many outstanding schools, a balanced and thriving economy, and a highly educated workforce.
Applications, sent by e-mail to Kathrin.Muegge@nih.gov, should consist of a cover letter describing research experience and interests, curriculum vitae, bibliography, and contact information for three references (including the current supervisor).
HHS, NIH, and NCI are Equal Opportunity Employers