Postdoctoral Fellow- Morphogenesis, Hedgehog Signaling

Staff Name: 
Susan Mackem, M.D., Ph.D.
Cancer and Developmental Biology Laboratory
Research Area Keywords: 

Morphogenesis, Hedgehog Signaling

Position Description: 

The Center for Cancer Research (CCR) is working to solve the most pressing problems in the field through basic, translational and clinical cancer research to create the cancer medicines of tomorrow and is dedicated to preparing the next generation of cancer researchers. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

The NCI CCR is dedicated to preparing the next generation of cancer researchers and offers a training environment that is second-to-none in quality of science and mentoring by outstanding principal investigators, including nine members of the National Academy of Science and eight members of the National Academy of Medicine. CCR offers fellows access to cutting-edge technologies and cores, a highly collaborative environment, awards and research forums to recognize outstanding post docs, continuous scientific symposia and lectures featuring leading researchers, a strong commitment to translational research, and a vibrant clinical research program housed in the world’s largest dedicated research hospital, the NIH Clinical Center.

We use Molecular genetic and genomic tools (including single cell seq) in the lab to understand how Sonic hedgehog patterns the limb via immediate target relays and by organizing late downstream signaling centers (Zhu & Mackem, Dev. Bio.  429:391-400, 2017; Huang et al, Nature Comm. 7:12903, 2016; Bowers et al, Dev. Bio. 370: 110-24, 2012; Zhu et al, Dev. Cell 14:624-32, 2008). Graded Gli3 repressor plays a major role in both early and late signaling centers.  A post-doctoral fellowship is available immediately to investigate the molecular basis for temporal integration of this signaling network, with a focus on Gli3 roles using combined genomic and proteomic approaches, including identification of interaction partners. 

Number of Positions: 
C.V. Required: 
Number of References Required: 
Experience Required: 

Successful applicant must have a doctoral degree (Ph.D., MD, DDS or the equivalent) in developmental biology, cell biology, molecular biology or a related field by the start date of their fellowship and less than 5 years of applicable postdoctoral research experience. Applicants may be U.S. citizens or permanent residents; for a visiting fellowship, visa requirements apply. An NIH provided background investigation is required. Postdoctoral Trainees will receive a stipend commensurate with their experience, and benefits include a FAES health insurance plan for fellow and qualifying family. 

Additional Information: 

CDBL’s research focuses on the analysis of embryonic development, particularly the mechanisms of growth control, the regulation of differentiation and morphogenesis through several signaling pathways that are also involved in cancer progression. The CDBL is comprised of six principal investigators who are exceptionally interactive and collaborative, prioritizing our trainee’s future success through weekly post-doc seminars, in-depth mentoring sessions, yearly combined retreats, lab group participation in regional scientific meetings, and more.

Additional information about the CDBL Investigators, their research programs, publications, and contact information may be found at

The CDBL is located on the NCI-Frederick National Laboratory campus at Ft. Detrick in historic Frederick, Maryland, a culturally vibrant, young and family-oriented community in close proximity to the greater Baltimore-Washington D.C urban area with easy access to the main NIH Bethesda campus and other prominent academic collaborating institutions.  Recreationally, the region features mountain hiking along the Appalachian trail, snow skiing, biking, kayaking, and other water activities along the Monocacy and Potomac rivers, the Chesapeake Bay, and Atlantic seaboard.

How To Apply: 

To apply, interested individuals may email their CV, a cover letter summarizing current and future research interests, along with contact information for three references directly to Susan Mackem, M.D., Ph.D., Head, Regulation of Vertebrate Morphogenesis Section, CDBL, NCI at

Contact Name: 
Susan Mackem
Contact E-mail: 

HHS, NIH, and NCI are Equal Opportunity Employers