Postdoctoral Fellow - Medicinal chemistry

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Name of Hiring Official/Investigator

Job Description

Opportunity. The Monteiro Group is seeking multiple postdoctoral researchers to join the Center for Structural Biology (CSB), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH). We are looking for enthusiastic and dedicated scientists to joining our team. Applicants should have an interest in medicinal chemistry. Successful candidates will join a highly interdisciplinary team and are expected to work closely with other team members. 

Research and Technology. Our research focuses on the determination of structures of oncogenic proteins and protein-ligand complexes, with an added interest in the study of protein dynamics and its correlation to function. The projects are split into two main areas of research:  determination of protein-ligand structures and high-throughput screening, and structural biology of oncogenic fusion proteins. As the synthetic organic chemist in the group, you will be expected to lead the medicinal chemistry projects in the laboratory, including the synthesis of active compounds, design of novel compounds with better biochemical characteristics and collaborate with biochemists to obtain protein-ligand structures and perform activity assays.

What we offer. The CSB offers a competitive salary and comprehensive health insurance. The positions are available immediately. Initial appointments will be for 1 year, with possible extension up to 5 years. The NIH is dedicated to building a diverse community in its training and employment programs as well as the continued education and career development of all its research staff. Numerous courses and workshops are offered by the NIH Office of Intramural Training and Education (OITE) and the Foundation for Advanced Education in the Sciences (FAES). These positions are subject to background checks. 

Qualifications and Job Details

Degree Required
Ph.D. or equivalent
Job Location
Appointment Type
Training Position (Starting stipend: $65,100, bonuses may apply)
Work Schedule
Full-time (In-Person)
US Citizenship not required - (ie, permanent resident, visa)

Required and Preferred Skills

Required Skills

Experience in organic synthesis, including small molecule purification and characterization, including the development of synthetic routes.

Strong track record in research, as published manuscripts or as conference participation.

Good communication skills and laboratory record keeping.

Excellent work ethic, motivation to work both independently and with team members.

Capability of working in a highly interdisciplinary and collaborative team, by sharing skills and learning from others. 

Preferred Skills

Experience in manuscript preparation, including writing and figure making.

Experience in compound screening (in vitro or in silico).

Basic knowledge of biochemistry or medicinal chemistry.

Basic knowledge of physical chemistry, especially spectroscopy.

About the NCI Center for Cancer Research

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.


Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views with a vibrant Main Street community. The city offers outstanding schools, a balanced and thriving economy and a highly educated workforce.

How to Apply
  • CV/Resume
  • 2 References
  • Cover Letter
  • Summary of Research Experience
Additional Application Information

Applicants should send a cover letter, indicating their preferred starting date, a brief description (1-2 pages) of past and current research, training goals, an up-to-date CV and contact details for 2 references, via email to

Contact Information
Contact Name
Diana C.F. Monteiro
E-mail Address
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.