Postdoctoral Fellow - Kinase, Cancer, Structure, Function
Kinase, Cancer, Structure, Function
The Center for Cancer Research (CCR) is working to solve the most pressing problems in the field through basic, translational and clinical cancer research to create the cancer medicines of tomorrow and is dedicated to preparing the next generation of cancer researchers. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
The NCI CCR is dedicated to preparing the next generation of cancer researchers and offers a training environment that is second-to-none in quality of science and mentoring by outstanding principal investigators, including nine members of the National Academy of Science and eight members of the National Academy of Medicine. CCR offers fellows access to cutting-edge technologies and cores, a highly collaborative environment, awards and research forums to recognize outstanding post docs, continuous scientific symposia and lectures featuring leading researchers, a strong commitment to translational research, and a vibrant clinical research program housed in the world’s largest dedicated research hospital, the NIH Clinical Center.
Dr. Zhang’s group studies the structural and mechanistic basis of kinases that are closely related to human cancers and many other diseases. Our main focus is on oncogenic kinases (including ALK, BRAF, Leucine Rich Repeat Kinase and PKA). We have also developed new collaborations within the CCR involving projects with propensity for translational application to the clinic, including the study of Microprocessor complex. We apply a combination of biochemical and structural (single-particle cryo-electron microscopy and X-ray crystallography) approaches to reveal the molecular mechanisms of such multi-component biological complexes and help to provide new strategies for therapeutic targeting.
The research of the group is supported by the collaborative and interdisciplinary NIH intramural program, which includes more than 1100 labs and provides state-of-the-art equipment in structural biology, biochemistry, and biophysics. These core facilities are supported by Ph.D-level staff and offer hands-on training. In addition, NIH is committed to the continuing education and career development of its research staff through numerous courses and workshops offered by NIH Office of Intramural Training & Education (OITE) and Foundation for Advanced Education in the Sciences (FAES). There are also opportunities for intramural career transition funding (K grants).
The candidate must have received a Ph.D. or M.D. degree within the past five years (or expecting one before Fall) in molecular biology, structural biology, biochemistry, or a related discipline. The candidate should have good oral and written skills in English. The candidate ought to be skilled in at least one of the following areas:
- Biochemistry and molecular biology (experience in protein purification from different expression systems and/or SPR, enzymology etc)
- Electron microscopy (experience in cryo-EM sample preparation and digital image processing). We have excellent access to high-end microscopes (Titan Krios equipped with K2 camera and Arctica equipped with K3 camera); testing microscopes are available and the computational infrastructure is setup and ready to go.
- Crystallography (experience in protein crystal structure determination). We have excellent access to Synchrotron beamline and in-house SAXS core.
The candidate must be highly motivated to participate in rigorous and innovative research programs, and possess excellent work ethic and team spirit: be able to work independently and efficiently and collaborate closely with members of the group and other labs on joint projects.
Frederick, the second largest city in Maryland, is the hub of Frederick County, Maryland. Frederick was named one of the Top 100 Best Places to Live and is located within an hour of the NIH main campus in Bethesda, Washington, D.C. and Baltimore, MD. The city offers many outstanding schools, a balanced and thriving economy and a highly educated workforce.
Please email a cover letter indicating preferred starting date, a brief description (1-2 pages) of past research, CV, and contact information for at least three references to firstname.lastname@example.org. Please state your area of interest in the application. Projects will be considered based on the applicant’s experience, interest, and creativity.
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