Postdoctoral Fellow - HTS assay development

Staff Name: 
Curtis J. Henrich, Ph.D.
Lab/Branch/Program: 
Molecular Targets Program
Location: 
Frederick
Research Area Keywords: 

HTS assay development pathway high content

Position Description: 

The Molecular Targets Program of the National Cancer Institute’s Center for Cancer Research has a postdoctoral position available in its Assay Development and Screening Section (ADSS).  The position is for assay development for both primary screening and mechanism of action (MOA) studies on the resulting bioactive compounds obtained from high-throughput screening (HTS) campaigns.  The laboratory’s areas of interest include the design and application of HTS assays around newly discovered cancer-related targets and mechanistic hit follow-up with a special emphasis on naturally occurring small molecules.  The selected candidate must have demonstrated expertise in utilization of cellular biochemical approaches to assay development or the elucidation of MOA of active compounds derived from phenotypic high-throughput screens.  Expertise in one or more of the following areas is desired: cell engineering for assay development, pathway/kinome prof  iling, high-content imaging assays, expression profiling, protein arrays for binding studies, yeast or mammalian chemical genetic and/or proteomic approaches, and in silico target prediction methods (and follow-up).  Candidates with experience with novel assays that can be developed into high throughput screens, or those with the application of CRISPR to the study of elucidation of signaling pathways, are particularly encouraged to apply.

Number of Positions: 
1
C.V. Required: 
Yes
Number of References Required: 
3
Experience Required: 

The candidate must have a Ph.D. in biochemistry, cell/molecular biology, or a related discipline from an accredited research institution within the last three years. 

Additional Information: 

The fellowship duration is 5 years based on performance and yearly evaluations. The fellowship is not restricted to U.S. citizens. The fellowship stipend starts at $54,100 per annum and is determined based on qualifications and years of relevant experience. 

How To Apply: 

Applicants should submit a cover letter, CV with bibliography, and three letters of reference to MTP_PostDoc@nih.gov

Contact Name: 
Curtis Henrich
Contact E-mail: 
Contact Phone: 
301-846-6054

HHS, NIH, and NCI are Equal Opportunity Employers