Postdoctoral fellow - Centrosome organization, Protein kinase
Centrosome organization, Protein kinase, Anti-cancer therapy
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The NCI Center for Cancer Research (CCR) is dedicated to preparing the next generation of cancer researchers and offers a training environment that is second-to-none in quality of science and mentoring by outstanding principal investigators, including nine members of the National Academy of Science and eight members of the National Academy of Medicine. CCR offers fellows access to cutting-edge technologies and cores, a highly collaborative environment, awards and research forums to recognize outstanding post docs, continuous scientific symposia and lectures featuring leading researchers, a strong commitment to translational research, and a vibrant clinical research program housed in the world’s largest dedicated research hospital, the NIH Clinical Center.
The architecture of a cell is established through varying degrees of hierarchical organizations from single molecules to macromolecular assemblies. Investigating how these molecules interact with one another to form a higher-order structural entity that offers a new biological function is a key step to unlocking the mystery of life. We are mainly interested in understanding the molecular basis of how diverse protein complexes are generated and how these complexes cooperate to generate a micron-scale self-assembly with distinct cellular functions. Recently, we found that mammalian polo-like kinase 4, a key regulator of centriole duplication, forms a high M.W. complex with centrosomal scaffolds, which generate a higher-order self-assembled architecture in a concentration-dependent manner. A failure in these events can result in abnormal centrosome numbers, improper spindle formation, and chromosome missegregation that ultimately lead to the development of various human diseases, including cancer, ciliopathy, and microcephaly. Thus, we aim to investigate the molecular mechanisms of how these proteins self-assemble into a higher-order architecture to promote cellular processes centrally required for cell cycle progression and proliferation.
Fellows who have an expertise in structural biology (X-ray or NMR), single molecule tracking, or cryo-EM are encouraged to apply.
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