Postdoctoral Fellow - cell biology, ubiquitin

Staff Name: 
Allan M. Weissman, M.D.
Laboratory of Protein Dynamics and Signaling
Research Area Keywords: 

cell biology, ubiquitin, protein degradation, ERAD

Position Description: 

A fully-funded postdoctoral position is available immediately in the Weissman lab in the Laboratory of Protein Dynamics and Signaling (LPDS), Center for Cancer Research, National Cancer Institute. Our focus on proteostasis includes regulated protein degradation and cellular quality control mechanisms involving the ubiquitin-proteasome system (UPS) particularly in the secretory pathway and mitochondria. We are especially interested in these as they relate to cellular stress, cancer and metastasis as well as cardiovascular disease. An additional area of interest is on structure-function relationships for RING-type ubiquitin protein ligases (E3s) and their interactions with ubiquitin conjugating enzymes (E2s). For more information, please see the Weissman website at

The Center for Cancer Research (CCR) is working to solve the most pressing problems in the field through basic, translational and clinical cancer research to create the cancer medicines of tomorrow and is dedicated to preparing the next generation of cancer researchers. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences. 

The NCI CCR is dedicated to preparing the next generation of cancer researchers and offers a training environment that is second-to-none in quality of science and mentoring by outstanding principal investigators, including nine members of the National Academy of Science and eight members of the National Academy of Medicine. CCR offers fellows access to cutting-edge technologies and cores, a highly collaborative environment, awards and research forums to recognize outstanding post docs, continuous scientific symposia and lectures featuring leading researchers, a strong commitment to translational research, and a vibrant clinical research program housed in the world’s largest dedicated research hospital, the NIH Clinical Center.

Number of Positions: 
C.V. Required: 
Number of References Required: 
Experience Required: 

Applicants should be completing, or have recently completed, a PhD or have an MD with limited relevant post-doctoral training. Appointees may be U.S. citizens, U.S permanent residents, or non-US residents eligible to obtain a valid employment authorization visa.

Applicants for this position should have a working knowledge of the ubiquitin-proteasome system and demonstrated expertise in biochemistry and cell biology. Applicants should also have an interest in working with, and potentially developing, animal models related to the ubiquitin-proteasome system and cancer. Experience in DNA manipulation as well as plasmid and siRNA transfection is a plus.

Additional Information: 

This position is located at CCR’s campus in Frederick, Maryland.  Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views, wineries, orchards, and a vibrant Main Street community.  It is less than an hour’s drive from the NIH main campus as well as the Appalachian Trail, Washington, D.C., Baltimore, and Gettysburg. The city offers many outstanding schools, a balanced and thriving economy, and a highly educated workforce.

Fellows in LPDS interact extensively with other scientists on both the Frederick and Bethesda campuses of NIH as well as with collaborators at other institutions.

How To Apply: 

Applicants should submit a cover letter, CV/Bibliography and names of three references to Allan Weissman at Please write “Postdoctoral application” in the subject line.

Contact Name: 
Allan Weissman
Contact E-mail: 

HHS, NIH, and NCI are Equal Opportunity Employers