Postdoctoral Fellow - Cancer Cell Biology; Functional Genetics

Staff Name: 
Natasha J. Caplen, Ph.D.
Genetics Branch
Research Area Keywords: 

Cancer Cell Biology; Functional Genetics; Transcription fact

Position Description: 

The Functional Genetics Section (Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI)) conducts multidisciplinary research using functional genetic approaches coupled with molecular, biochemical, and cell biology-based methods to interrogate the genetic, transcriptional, and cell-signaling alterations observed in cancer cells. Our current research focuses on cancers driven by fusion oncoproteins, including the study of the reprogramming of the transcriptome and signaling networks by fusion transcription factors. We are seeking a motivated candidate interested in the study of the changes in the transcriptome and signaling networks in a fusion transcription factor-driven cancer that influences cell-cell and cell-matrix interactions. The successful applicant will apply molecular, biochemical, and cellular approaches to assess the function of selected genes-of-interest involved in the regulation of cell-cell and cell-matrix interactions. We work with many other investigators within the intramural program and take advantage of the uniqueness of the CCR intramural program in that our studies span fundamental discovery through preclinical translational research, as well as CCR’s many core facilities. The CCR also offers many career development opportunities for scientists early in their careers.

CCR is working to solve the most pressing problems in the field through basic, translational and clinical cancer research to create the cancer medicines of tomorrow and is dedicated to preparing the next generation of cancer researchers. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

CCR is dedicated to preparing the next generation of cancer researchers and offers a training environment that is second-to-none in quality of science and mentoring by outstanding principal investigators, including nine members of the National Academy of Science and eight members of the National Academy of Medicine. CCR offers fellows access to cutting-edge technologies and cores, a highly collaborative environment, awards and research forums to recognize outstanding post docs, continuous scientific symposia and lectures featuring leading researchers, a strong commitment to translational research, and a vibrant clinical research program housed in the world’s largest dedicated research hospital, the NIH Clinical Center. 

Number of Positions: 
C.V. Required: 
Number of References Required: 
Experience Required: 

We are seeking self-motivated candidates with Ph.D. or M.D. degree, or equivalent, in molecular/cell biology or biochemistry, or related disciplines, ideally with additional training in cancer and transcription factor biology. Applicants should have demonstrated a record of accomplishment, as evidenced by at least one first-author paper and a commitment to performing cancer research at the highest level. Prior experience growing cancer cells in 3D-format will be advantageous, as will experience applying genome or transcriptome-scale analysis methods. The candidate must have excellent organizational and communication skills and fluency in both verbal and written English.

Additional Information: 

Bethesda, located adjacent to Washington, D.C., is an urban core of Montgomery County, MD. Bethesda is one of the most affluent and highly educated communities in the United States. Living in Bethesda offers residents a suburban feel with a lot of restaurants, coffee shops, and parks. The public schools in Bethesda are highly rated.

This position is subject to a background investigation. This position is available immediately. Stipends are commensurate with education and experience. Please see Dr. Caplen’s profile page: for additional information.

How To Apply: 

Applicants should submit a cover letter describing their research experience and interests, CV, including bibliography, and contact information for three references to Dr. Caplen, Ph.D., via e-mail: No calls, please. If we are interested, Dr. Caplen will be in contact.

Contact Name: 
Natasha Caplen
Contact E-mail: 

HHS, NIH, and NCI are Equal Opportunity Employers