Postdoctoral Fellow - cancer biology, protein chemistry

Staff Name: 
Chun Zhang Yang, Ph.D.
Neuro-Oncology Branch
Research Area Keywords: 

cancer biology, protein chemistry, brain tumor

Position Description: 

A postdoctoral position is available in the Molecular and Cell Biology Section ( in Neuro-Oncology Branch (NOB), Center for Cancer Research (CCR), National Cancer Institute (NCI) of the National Institutes of Health (NIH).  

The position is offered to explore the role of oncometabolite and molecular signaling in brain tumors. The research will involve a systematic investigation of the epigenetic changes in oncometabolite-driven cancers. Genetic and biochemical approaches will be employed to characterize the critical epigenetic targets among pathways of DNA repair, metabolism, and therapy resistance. The mechanistic findings will be verified through proof-of-concept investigation with the latest in vitro and in vivo models, as well as patient-derived specimens for validation. Experimental therapeutics are designed based on our preliminary findings, which provide strong justifications for future clinical translation and application.

Besides being a unique research opportunity in an emerging field with important basic/translational implications, our laboratory will support initiatives to strengthen the scientific career of postdoctoral trainees per the level and achievements demonstrated.

CCR is working to solve the most pressing problems in the field through basic, translational and clinical cancer research to create the cancer medicines of tomorrow and is dedicated to preparing the next generation of cancer researchers. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences. 

The NCI CCR is dedicated to preparing the next generation of cancer researchers and offers a training environment that is second-to-none in quality of science and mentoring by outstanding principal investigators, including nine members of the National Academy of Science and eight members of the National Academy of Medicine. CCR offers fellows access to cutting-edge technologies and cores, a highly collaborative environment, awards and research forums to recognize outstanding post docs, continuous scientific symposia and lectures featuring leading researchers, a strong commitment to translational research, and a vibrant clinical research program housed in the world’s largest dedicated research hospital, the NIH Clinical Center.

Number of Positions: 
C.V. Required: 
Number of References Required: 
Experience Required: 
Successful candidates should:
1. be highly motivated, able to conduct semi-independent research and function as part of an interdisciplinary team;
2. have strong expertise in the fields of cancer biology, molecular biology, biochemistry, epigenetics, and bioinformatics;
3. have direct experience with many of the following laboratory techniques: cell culture and transfection, epigenetics, DNA/protein methylation profiling, protein complex profiling, chromatin immunoprecipitation (ChIP), Next-generation sequencing, ChIP-Seq, DNA cloning, and subcloning, and site-directed mutagenesis;
4. have expertise in confocal microscopy, flow cytometry and intracranial/subcutaneous mouse xenograft models;
5. possess excellent communication skills and be fluent in both spoken and written English.
Applicants should have a Ph.D. degree, preferably in biochemistry, molecular biology, genetics, or related field, be near completion of degree requirements, and have no more than five years of postdoctoral research experience.
Additional Information: 

Bethesda, located adjacent to Washington, D.C., is an urban core of Montgomery County, MD. Bethesda is one of the most affluent and highly educated communities in the United States. Living in Bethesda offers residents a suburban feel with a lot of restaurants, coffee shops, and parks. The public schools in Bethesda are highly rated.

How To Apply: 

Please email curriculum vitae, statement of research interests, and three letters of reference to the attention of: Chunzhang Yang, Ph.D., Neuro-Oncology Branch, National Cancer Institute, 37 Convent Drive, Room 1142E, Bethesda, MD 20892 at

Contact Name: 
Chunzhang Yang
Contact E-mail: 
Contact Phone: 

HHS, NIH, and NCI are Equal Opportunity Employers