Postdoctoral Fellow - Cancer biology, protein chemistry

Staff Name: 
Chun Zhang Yang, Ph.D.
Neuro-Oncology Branch
Research Area Keywords: 

Cancer biology, protein chemistry, brain tumor

Position Description: 

The Neuro-Oncology Branch (NOB), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) is seeking outstanding postdoctoral candidates for laboratory research related to brain tumors.  NOB is comprised of a multidisciplinary team of physicians, healthcare providers, and scientists who are dedicated to developing new therapies and improving outcomes for patients with primary brain and spinal cord tumors.

One postdoctoral fellow position is available in the Molecular and Cell Biology (MCB) Section of the NOB laboratory in its exciting translational, interdisciplinary research team.  NOB seeks creative and bright individuals who have a keen interest in making a substantial contribution to the understanding of the function of oncometabolites, ranging from D-2-hydroxyglutarate, succinate and fumarate.  The MCB employs translational techniques to explore the biologic function of oncometabolites, with a focus on the post-translational modifications throughout the proteomics.  Further, we establish proof-of-concept investigation with the latest in vitro and in vivo models, as well as patient-derived specimens for validation. Our ongoing efforts also include studying the cancer vulnerability pathways in oncometabolite-driven cancers for future molecular targeting.  Experimental therapeutics are designed based on our preliminary findings, which provides strong justification for future clinical translation and application.

CCR is working to solve the most pressing problems in the field through basic, translational and clinical cancer research to create the cancer medicines of tomorrow and is dedicated to preparing the next generation of cancer researchers. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

CCR is dedicated to preparing the next generation of cancer researchers and offers a training environment that is second-to-none in quality of science and mentoring by outstanding principal investigators, including nine members of the National Academy of Science and eight members of the National Academy of Medicine. CCR offers fellows access to cutting-edge technologies and cores, a highly collaborative environment, awards and research forums to recognize outstanding post docs, continuous scientific symposia and lectures featuring leading researchers, a strong commitment to translational research, and a vibrant clinical research program housed in the world’s largest dedicated research hospital, the NIH Clinical Center.

Number of Positions: 
C.V. Required: 
Number of References Required: 
Experience Required: 

Successful candidates should have 1) a strong research background in cancer biology, and especially the use of molecular/cellular approaches to investigate cancer biology and malignant phenotype is strongly encouraged; 2) the ability to conduct semi-independent research and function as part of an interdisciplinary team; 3) direct experience with many of the following laboratory techniques: cell culture, cell transfection, ELISA, Western blotting, protein complex profiling, chromatin immunoprecipitation (ChIP), Sanger Sequencing, ChIP-Seq, PCR, DNA cloning and subcloning, and site-directed mutagenesis; 4) expertise in confocal microscopy, flow cytometry and intracranial/subcutaneous mouse xenograft models; and 5) possess good communications skills and be fluent in both spoken and written English.

Applicants should have a Ph.D. degree, preferably in biochemistry, molecular biology, genetics, or related field, be near completion of degree requirements, and have no more than three years of postdoctoral research experience.

Additional Information: 

Bethesda, located adjacent to Washington, D.C., is an urban core of Montgomery County, MD. Bethesda is one of the most affluent and highly educated communities in the United States. Living in Bethesda offers residents a suburban feel with a lot of restaurants, coffee shops, and parks. The public schools in Bethesda are highly rated.

How To Apply: 

Please email curriculum vitae, statement of research interests, and three letters of reference to the attention of:  Chunzhang Yang, Ph.D., Neuro-Oncology Branch, National Cancer Institute, 37 Convent Drive, Room 1142E, Bethesda, MD 20892 at

Contact Name: 
Chunzhang Yang
Contact E-mail: 
Contact Phone: 

HHS, NIH, and NCI are Equal Opportunity Employers