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Center for Cancer Research

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Post-doctoral Fellow - Metabolomics via NMR

Job Description:

Position is with:

The Neuro-Oncology Branch (NOB), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) is seeking an outstanding postdoctoral candidate for laboratory research related to brain tumors.  The postdoctoral position is available in NOB's Metabolomics program, which is focused on understanding the metabolic changes in brain tumors such as glioblastoma multiforme (GBMs).  In particular, the Metabolomics program is interested in revealing the metabolic alterations of isocitrate dehydrogenase (IDH1)-mutated GBMs and in exploiting these deregulations for therapeutic applications.  A combination of methods are employed in this work, such as molecular biology, animal models, as well as in vitro and in vivo metabolomics using Raman Imaging Microscopy, Nuclear Magnetic Resonance (NMR) spectroscopy, Mass Spectrometry (MS) and Magnetic Resonance Imaging (MRI) techniques.

The postdoctoral position will focus on NMR metabolomics research, which requires expertise in NMR, mammalian cell culture and other common biomedical techniques used in cancer biology labs such as handling tissue samples, preparing samples using 13C labeling, extraction of metabolites brain tissue and cells.

Responsibilities and Duties

  1. Carry out metabolomics-based NMR data acquisition and analysis
  2. Writing manuscripts
  3. Presenting data at meetings and conferences
  4. Collaborating with other team members to finish projects

Qualifications and Job Details:

  • Degree Required: Ph.D. or equivalent
  • Location: Bethesda, Maryland
  • Appointment Type: Training Position
  • Work Schedule: Full-time position
  • Citizenship: US Citizenship not required - (ie, permanent resident, visa)
  • Stipend: Commensurate with experience

REQUIRED SKILLS:

Applicants should have a Ph.D. and/or M.D., relevant experience highlighted above, and less than 3 years of postdoctoral experience.

PREFERRED SKILLS:

Successful candidates should have:

  • Training in NMR spectroscopy for metabolomics.
  • Experience in handling cell culture and extracting metabolites.
  • Experience in manipulating human cell lines, such as neurospheres, different tissue, blood and urine samples.
  • Be highly independent in designing the experiments, analyzing the data and presenting the results.
  • Manuscript writing skills.

About the NCI Center for Cancer Research:

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply:

Submit:
  • CV/Resume
  • Statement of Research Goals
  • Three References
  • Bibliography

Additional Application Information:

Please email curriculum vitae, statement of research interests, and three letters of reference to the attention of:  Mioara Larion, Ph.D., Neuro-Oncology Branch, National Cancer Institute, 37 Convent Drive, Room 1136A, Bethesda, MD 20892 at mioara.larion@nih.gov.

Contact Name: Mioara Larion, Ph.D.

Contact Email: mioara.larion@nih.gov

For questions contact: Mioara Larion, Ph.D., mioara.larion@nih.gov

HHS, NIH, and NCI are Equal Opportunity Employers