Center for Cancer Research

To improve the lives of cancer patients by solving important, challenging and neglected problems in cancer research and patient care.

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Post-doctoral Fellow - Kinase, structural biology

Job Description:

Position is with:

A postdoctoral position is available in The Kinase Complexes Section (KCS), Structural Biophysics Laboratory (SBL), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Frederick, MD.  The candidate will perform basic research in molecular biology/structural biology/biochemistry.

The KCS group studies the structural and mechanistic basis of kinases that are closely related to human cancers and many other diseases. Our focus is on oncogenic kinases (including RAF, Leucine Rich Repeat Kinase and PKA). We apply a combination of biochemical and structural (single-pai1icle cryo-electron microscopy and X-ray crystallography) approaches to reveal the molecular mechanisms of such multi-component biological complexes and help to provide new strategies for therapeutic targeting.

Qualifications and Job Details:

  • Degree Required:
    • Ph.D. or equivalent
    • M.D. or equivalent
  • Location: Frederick, Maryland
  • Appointment Type: Training Position
  • Work Schedule: Full-time position
  • Citizenship: US Citizenship not required - (ie, permanent resident, visa)
  • Stipend: Commensurate with experience

REQUIRED SKILLS: Applicants must have a strong background in molecular biology, structural biology, enzymology, biochemistry, or a related discipline. The candidate should have good oral and written skills in English. The candidate should be skilled in at least one of the following areas: biochemistry and molecular biology (experience in protein purification from different expression systems and/or enzymology, etc.); electron microscopy (experience in cryo-EM sample preparation and digital image processing); or crystallography (experience in protein crystal structure determination). We have excellent access to high-end microscopes (Titan Krios equipped with K2 camera and Arctica equipped with K3 camera), testing microscopes are available, and the computational infrastructure is setup. We also have excellent access to the Synchrotron beamline and an in-house SAXS core. The candidate must be highly motivated to participate in rigorous and innovative research programs and possess excellent work ethic and team spirit, be able to work independently and efficiently, and collaborate closely with members of the group and other labs on joint projects.

About the NCI Center for Cancer Research:

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views with a vibrant Main Street community. The city offers outstanding schools, a balanced and thriving economy and a highly educated workforce.

How to Apply:

  • CV/Resume
  • Three References
  • Cover Letter
  • Summary of Research Experience

Contact Name: Ping Zhang

Contact Email:

For questions contact: Ping Zhang,

HHS, NIH, and NCI are Equal Opportunity Employers