Center for Cancer Research
To improve the lives of cancer patients by solving important, challenging and neglected problems in cancer research and patient care.
Post-doctoral Fellow - immunology, immunotherapy, metastasis, TME, computational
Position is with:
This is an exciting opportunity to join a translational research program focused on the role of the host microenvironment in establishing metastasis. Our research has established the concept of the pre-metastatic niche (Nature 2005, Nature Medicine 2017) which demonstrates myeloid cells and stromal cells promote cancer metastasis by establishing a conducive microenvironment that regulates tumor cell growth and survival. Current research focuses on the basic understanding of normal and abnormal stem cell niche biology, tumor-host interaction, immune response to cancer metastasis and development of new immunotherapies to manipulate the early metastatic microenvironment to restore immune balance and tissue homeostasis. Our laboratory has extensive syngeneic metastatic tumor models, lineage tracing models to study specific populations within the metastatic microenvironment and highly metastatic human and murine models, as well as access to many diverse clinical samples. Projects involve: development of novel immunotherapy approaches that can prevent or reverse metastatic progression, translational studies involving patient blood and tissue samples focused on scRNA sequencing, CRISPR, flow cytometry, the use of 3d in vitro models and mouse models with molecular and cellular biology technologies to develop deeper understanding of the metastatic process.
Qualifications and Job Details:
- Degree Required:
- Ph.D. or equivalent
- M.D. or equivalent
- Location: Bethesda, Maryland
- Appointment Type: Training Position
- Work Schedule: Full-time position
- Citizenship: US Citizenship not required - (ie, permanent resident, visa)
- Stipend: Commensurate with experience
REQUIRED SKILLS: Applicants with a strong background in immunology, cancer immunotherapy, myeloid cell biology, cell biology, hematopoietic stem cell niche biology and computational experience or interest are encouraged to apply.
About the NCI Center for Cancer Research:
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.
How to Apply:Submit:
- Three References
- Summary of Research Experience
Contact Name: Tiffany Prout
Contact Email: email@example.com
For questions contact: Tiffany Prout, firstname.lastname@example.org
HHS, NIH, and NCI are Equal Opportunity Employers