NCI’s
Center for Cancer Research

To improve the lives of cancer patients by solving important, challenging and neglected problems in cancer research and patient care.

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Post-doctoral Fellow - Hematopoietic Cell Transplantation Immunology

Job Description:

Position is with:

We are recruiting a highly motivated Postdoctoral Research Fellow to study the biology of graft-versus-host disease (GVHD) and mechanisms of its prevention after allogeneic hematopoietic cell transplantation (HCT).  Projects will include extensive high-dimensional immunophenotyping of samples from patients with chronic GVHD as well as mechanistic studies in murine HCT models.

Allogeneic HCT is a potentially curative therapy for otherwise incurable hematologic malignancies.  The use of post-transplantation cyclophosphamide (PTCy) as GVHD prophylaxis recently has revolutionized the HCT field by making HCT available to nearly all patients and effectively preventing both severe acute and chronic GVHD.  However, the mechanisms underlying PTCy’s clinical efficacy have been poorly understood.  Recent work performed in the laboratory of Dr. Christopher Kanakry (e.g., https://www.jci.org/articles/view/124218 and https://www.frontiersin.org/articles/10.3389/fimmu.2019.02668/full) has disproven the existing paradigm of understanding, and we are actively developing a comprehensive new mechanistic model.  Simultaneously, we are using these new biologic understandings to rationally improve transplantation approaches through the direct translation in early-phase clinical trials.

Candidates should have a Ph.D. and/or M.D. degree.  Substantial experience in relevant techniques, particularly high-dimensional flow cytometry and mouse modeling, is preferred.  The successful applicant will join the laboratory of Dr. Christopher Kanakry, Lasker Clinical Research Scholar/Tenure-Track Investigator, within the Experimental Transplantation and Immunotherapy Branch, CCR, NCI, NIH.  The Kanakry Laboratory utilizes cellular and molecular immunologic tools to address mechanistic and translational questions with direct relevance for improving outcomes of patients undergoing HCT.  The Kanakry Laboratory is within the broader NCI community, which provides a vibrant and enriching environment for research in immunology, immunotherapy, transplantation, and cancer with ready access to numerous cutting-edge technologies.

Qualifications and Job Details:

  • Degree Required:
    • Ph.D. or equivalent
    • M.D. or equivalent
  • Location: Bethesda, Maryland
  • Appointment Type: Training Position
  • Work Schedule: Full-time position
  • Citizenship: US Citizenship not required - (ie, permanent resident, visa)
  • Stipend: Commensurate with experience

REQUIRED SKILLS:

immunology

PREFERRED SKILLS:

high-dimensional flow cytometry and mouse modeling

About the NCI Center for Cancer Research:

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply:

Submit:
  • CV/Resume
  • Statement of Research Goals
  • Three References
  • Cover Letter
  • Summary of Research Experience

Additional Application Information:

Information about Dr. Kanakry and his laboratory can be found at https://ccr.cancer.gov/Experimental-Transplantation-and-Immunotherapy-Branch/christopher-g-kanakry.  Applicants should contact Dr. Kanakry directly at christopher.kanakry@nih.gov.

Contact Name: Christopher Kanakry

Contact Email: christopher.kanakry@nih.gov

For questions contact: Christopher Kanakry, christopher.kanakry@nih.gov

HHS, NIH, and NCI are Equal Opportunity Employers