Post-doctoral Fellow - Computational structural biology, integrative modeling

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Name of Hiring Official/Investigator

Job Description

The O’Reilly lab is seeking a postdoctoral fellow who wants to join our interdisciplinary team to integrate whole-cell crosslinking mass spectrometry and cryo-electron microscopy with protein complex modeling and structure prediction. See and

We have projects that include large-scale protein interactome mapping and more focused structural biology applications. There are two major study areas:

  1. Discovering and characterizing novel protein complexes across the human microbiome.
  2. Understanding structural changes in human protein complexes on the path to cancer.

For more information see

Qualifications and Job Details

Degree Required
Ph.D. or equivalent
Job Location
Appointment Type
Training Position (Stipend commensurate with experience)
Work Schedule
US Citizenship not required - (ie, permanent resident, visa)

Required and Preferred Skills

Required Skills

Candidates must have a Ph.D. in chemistry, biochemistry, computer science, or similar. Candidates will have significant training and hands-on expertise in computational structural biology, including experience in one or more of integrative modeling, docking, model building, or protein structure prediction. Candidates must have coding experience and experience with machine learning approaches will be beneficial. The candidate needs to be prepared to interact closely with experimentalists. Effective teamwork, communication skills, and the ability to participate in an interdisciplinary collaboration are key requirements.

About the NCI Center for Cancer Research

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.


Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views with a vibrant Main Street community. The city offers outstanding schools, a balanced and thriving economy and a highly educated workforce.

How to Apply
  • CV/Resume
  • 3 References
  • Cover Letter
Additional Application Information

The research group is supported by the collaborative and interdisciplinary NIH Intramural Research Program and offers a competitive salary and comprehensive health insurance. Appointments will be two years initially and renewable up to a total of 5 years based on performance. The NIH is dedicated to building a diverse community in its training and employment programs. Applications from international candidates are welcomed.

What we offer:

  • Fully funded postdoctoral research position within the Center for Structural Biology at the Center for Cancer Research (CCR), National Cancer Institute (NCI)
  • Access to cutting-edge computational resources
  • Modern laboratory with its own Orbitrap Eclipse Tribrid Mass Spectrometer and access to state-of-the-art core facilities including gene editing, next-generation sequencing, cryo-EM, SAXS, NMR, and cell imaging
  • A small collaborative team with regular supportive access to the group leader
  • Highly collaborative and growing research environment
  • A family-friendly, accessible, and supportive workplace

The Institute: The research of the group is supported by the collaborative and interdisciplinary NIH intramural program, which includes more than 1100 labs and provides state-of-the-art equipment in structural biology, biochemistry, and biophysics. These core facilities are supported by Ph.D.-level staff and offer hands-on training. In addition, NIH is committed to the continuing education and career development of its research staff through numerous courses and workshops offered by NIH Office of Intramural Training & Education (OITE) and Foundation for Advanced Education in the Sciences (FAES). There are also opportunities for intramural career transition funding (K grants).

How to Apply: Applicants should send a cover letter, CV including a bibliography, and contact information for three references to Francis O’Reilly at

Contact Information
Contact Name
Francis O'Reilly
E-mail Address
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.