Center for Cancer Research

To improve the lives of cancer patients by solving important, challenging and neglected problems in cancer research and patient care.

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Post-doctoral Fellow - Chromatin, Cancer, Cell Cycle, Chromosome Duplication, Epigenetics

Job Description:

Position is with:

postdoctoral position is available at the DNA Replication Group (PI: Mirit I. Aladjem, Ph.D.), a part of the NCI’s Developmental Therapeutics Branch in Bethesda, Maryland. Our group aims to understand cellular networks that signal to and from chromatin to modulate DNA replication. Since many regulatory feedback pathways are deregulated in cancer cells, the results of these studies will help our understanding of cancer biology and thmechanisms underlying therapeutic strategies. 

The project builds on our recent comprehensive analyses of distinct protein-DNA interactions associated with human replication origins, shown to modulate the progress of DNA replication. Our research strategy combines sequencing-based analyses with single-fiber studies to identify specific replication and repair pathways that affect the pace and frequency of DNA replication. We use these tools to ask how the molecular interactions that affect DNA replication respond to environmental challenges and how modulation of these responses affect the sensitivity of malignant cells to anti-cancer therapy. 

Training opportunities are augmented by collaborations with colleagues, physicians and pharmacologists from the intramural and extramural communities. Fellows are encouraged to take advantage of formal, focused courses (e.g. training in bioinformatics and translational research), actively engage in mentoring and participate in a variety of community activities including the NIH’s cell cycle interest group, DNA repair interest group and the NCI's Center of Excellence in Chromosome Biology.  

More information about the group and the NCI’s Developmental Therapeutics Branch can be found at:

Qualifications and Job Details:

  • Degree Required:
    • Ph.D. or equivalent
    • M.D. or equivalent
  • Location: Bethesda, Maryland
  • Appointment Type: Training Position
  • Work Schedule: Full-time position
  • Citizenship: US Citizenship not required - (ie, permanent resident, visa)
  • Stipend: Commensurate with experience


A Ph.D. or M.D. degree reflecting training in molecular, cellular or cancer biology, biochemistry and/or bioinformatics.

About the NCI Center for Cancer Research:

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply:

  • CV/Resume
  • Cover Letter

Additional Application Information:

To apply, please contact the principal investigator by email:

Contact Name: Dr, Mirit Aladjem

Contact Email:

For questions contact: Dr, Mirit Aladjem,

HHS, NIH, and NCI are Equal Opportunity Employers