NCI’s
Center for Cancer Research

To improve the lives of cancer patients by solving important, challenging and neglected problems in cancer research and patient care.

Join us!

Post-doctoral Fellow - Centrosome, centriole, microscopy

Job Description:

Position is with:

Our laboratory studies the fundamentals of centrosome biology. Centrosomes are cellular organelles that mediate vital cellular processes such as cell division, signaling, motility and development. Supernumerary and structurally aberrant centrosomes can initiate tumorigenesis, promote tumor invasiveness and are present in most aggressive tumors. It is still not understood how centriole/centrosome biogenesis is controlled at a mechanistic level.

We employ a multiprong experimental approach combining biochemistry, genetics, proteomics, and imaging. In imaging studies, we use cutting-edge microscopy approaches such as live-cell and super resolution microscopy (SIM, STED, STORM), expansion microscopy, transmission electron microscopy, and correlative light and electron microscopy (CLEM).

The fellow will investigate the mechanisms that drive centriole and centrosome biogenesis and join our efforts in dissecting centrosome architecture in nanoscale resolution. The studies will be conducted on various human cancer cells, combining biochemistry, genetics, proteomics, and imaging. In imaging studies, the fellow will use cutting-edge microscopy approaches such as live-cell and super resolution microscopy (SIM, STED, STORM), expansion microscopy, transmission electron microscopy, and correlative light and electron microscopy (CLEM).

The fellow will work in a dynamic and collaborative group and with an extensive network of intramural and extramural researchers. 

Qualifications and Job Details:

  • Degree Required:
    • Ph.D. or equivalent
    • M.D. or equivalent
  • Location: Frederick, Maryland
  • Appointment Type: Training Position
  • Work Schedule: Full-time position
  • Citizenship: US Citizenship not required - (ie, permanent resident, visa)
  • Stipend: Commensurate with experience

REQUIRED SKILLS:

We are looking for candidates with a strong interest in cell biology and microscopy. Candidates must have a good command of basic biochemistry techniques, molecular cloning, and mammalian cell culture. The successful candidate must have proven analytical, communication, and problem-solving skills.

PREFERRED SKILLS:

Experience in microscopy is an advantage.

About the NCI Center for Cancer Research:

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views with a vibrant Main Street community. The city offers outstanding schools, a balanced and thriving economy and a highly educated workforce.

How to Apply:

Submit:
  • CV/Resume
  • Three References
  • Summary of Research Experience
  • Statement of interest

Additional Application Information:

Please send your CV, references, and Statement of Interest to jadranka.loncarek@nih.gov.

Contact Name: Jadranka Loncarek

Contact Email: jadranka.loncarek@nih.gov

For questions contact: Jadranka Loncarek, jadranka.loncarek@nih.gov

HHS, NIH, and NCI are Equal Opportunity Employers