Center for Cancer Research

To improve the lives of cancer patients by solving important, challenging and neglected problems in cancer research and patient care.

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Post-doctoral Fellow - cell biology, ubiquitin, breast cancer

Job Description:

Position is with:

A postdoctoral position is available immediately in the Weissman group in the Laboratory of Protein Dynamics and Signaling (LPDS) to study and the roles of the ubiquitin-proteasome system in cellular proteostasis with a focus on mitochondria and the secretory pathway, principally the endoplasmic reticulum. Goals of ongoing work in our highly collaborative group are to understand the roles of the ubiquitin-proteasome system in pathological states including: cancer growth and metastasis; cardiovascular disease; and viral pathogenicity, particularly SARS-CoV-2/COVID-19 and botulism. Our research employs state-of-the-art cell biological, biochemical, biophysical, proteomic, and genetic approaches. In vivo systems range from yeast and mammalian cell culture to mouse models of human disease and human cancers. For additional information, please see the Weissman website at

The Laboratory of Protein Dynamics and Signaling is located on the Frederick campus of the NCI where trainees have access to a unique range of NCI core facilities and the immense breadth of expertise characteristic of the NCI intramural program. We collaborate and interact extensively with scientists throughout the NIH Intramural Program, which is facilitated by both facile electronic communication and regular shuttles that connect the Frederick and Bethesda campuses of NIH.

Qualifications and Job Details:

  • Degree Required:
    • Ph.D. or equivalent
    • M.D. or equivalent
  • Location: Frederick, Maryland
  • Appointment Type: Training Position
  • Work Schedule: Full-time position
  • Citizenship: US Citizenship not required - (ie, permanent resident, visa)
  • Stipend: Commensurate with experience


Applicants should be completing, or have recently completed, a Ph.D. or have an M.D. with limited relevant post-doctoral training.

Appointees may be U.S. citizens, U.S permanent residents, or non-U.S. residents eligible to obtain a valid employment authorization visa.

Candidates must be able to provide strong letters of recommendation upon request.


Applicants for this position should have demonstrated expertise in biochemistry and cell biology. A working knowledge of the ubiquitin-proteasome system is a plus. 

About the NCI Center for Cancer Research:

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views with a vibrant Main Street community. The city offers outstanding schools, a balanced and thriving economy and a highly educated workforce.

How to Apply:

  • CV/Resume
  • Statement of Research Goals
  • Cover Letter
  • Summary of Research Experience

Additional Application Information:

Please include ‘Postdoctoral Application’ in the subject line of emails to Dr. Weissman.

Applicants should provide names and contact information for at least three referees. Please do not submit reference letters until requested.

Contact Name: Allan Weissman

Contact Email:

For questions contact: Allan Weissman,

HHS, NIH, and NCI are Equal Opportunity Employers