Center for Cancer Research

To improve the lives of cancer patients by solving important, challenging and neglected problems in cancer research and patient care.

Join us!

Post-doctoral Fellow - Cancer Biology, Stem Cell Biology, Epigenetics

Job Description:

Position is with:

The Epigenetics Section, headed by Dr. Kathrin Muegge has an open post-doctoral position. The Epigenetics Section studies the causes and consequences of the ICF4 syndrome, a complex disease with symptoms of immunodeficiency, genomic instability, mental retardation and compromised germ cell development. Genetic mutations of Lsh/HELLS, a chromatin remodeling protein, can cause the ICF4 syndrome. Lsh modulates genome-wide chromatin accessibility, influences DNA methylation levels and alters retrotransposon expression. Using mouse models with tissue-specific deletions of Lsh we are using a variety of molecular and cell biologic techniques to determine chromatin states in affected tissues during development. Uncovering molecular pathways will deepen our understanding of the pathophysiology underlying this disease and should help to identify novel molecular targets for therapeutic intervention.

Qualifications and Job Details:

  • Degree Required:
    • Ph.D. or equivalent
    • M.D. or equivalent
  • Location: Frederick, Maryland
  • Appointment Type: Training Position
  • Work Schedule: Full-time position
  • Citizenship: US Citizenship not required - (ie, permanent resident, visa)
  • Stipend: Commensurate with experience

REQUIRED SKILLS: Applicants must have a Ph.D. and expertise in molecular biology, genetics, biochemistry, and cell biology. We are looking for a candidate who possesses an exceptional motivation for academic research and less than 1-year of postdoctoral experience. Those with experience in germ cell development, neurobiology and epigenetics are particularly encouraged to apply. Good oral and written communication skills are required.

About the NCI Center for Cancer Research:

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views with a vibrant Main Street community. The city offers outstanding schools, a balanced and thriving economy and a highly educated workforce.

How to Apply:

  • CV/Resume
  • Statement of Research Goals
  • Three References
  • Cover Letter
  • Summary of Research Experience

Additional Application Information:

Applications, sent by e-mail to, should consist of a cover letter describing research experience and interests, curriculum vitae, bibliography, and contact information for three references (including the current supervisor).

Please visit Dr. Muegge’s webpage for further information.

Contact Name: Kathrine Muegge

Contact Email:

For questions contact: Iben Hanson,

HHS, NIH, and NCI are Equal Opportunity Employers