NCI’s
Center for Cancer Research

To improve the lives of cancer patients by solving important, challenging and neglected problems in cancer research and patient care.

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Post-doctoral Fellow - antibody engineering, phage display

Job Description:

Position is with:

A postdoctoral fellow position is available immediately in the Antibody Engineering Core (AEP) at the Center for Cancer Research (CCR), National Cancer Institute (NCI) in Bethesda, Maryland, USA. The core web site: https://ostr.ccr.cancer.gov/resources/antibody-engineering-program/.

Single domain antibodies (also known as ‘nanobodies’) have the ability to reach buried sites, bind poorly immunogenic antigens, reveal protein structures, and have cross-species functional activities. Additionally, nanobodies are small and easily expressed in both bacteria and mammalian cells. These features make them attractive for incorporating into therapeutics such as CAR T cells, multispecific/multifunctional antibodies, ADCs and immunotoxins. Dr. Mitchell Ho’s laboratory at the NCI constructed large phage-displayed shark and camel nanobody libraries [https://pubmed.ncbi.nlm.nih.gov/30627698/]. Using these unique single domain libraries, the Antibody Engineering Core collaborates with intramural labs to identify nanobodies for solving important biological problems as well as treating cancer, viral infections and other human diseases.

Qualifications and Job Details:

  • Degree Required: Ph.D. or equivalent
  • Location: Bethesda, Maryland
  • Appointment Type: Training Position
  • Work Schedule: Full-time position
  • Citizenship: US Citizenship not required - (ie, permanent resident, visa)
  • Stipend: Commensurate with experience

REQUIRED SKILLS:

Candidates should have received a Ph.D. in molecular biology, biochemistry, structure biology or a related discipline. The ideal candidate should have research expertise in antibody engineering including phage display, directed evolution and computational analysis of antibody sequences or structures. Applicants should have at least one first-author research publication in antibody or protein engineering. Excellent oral and written communication skills are also required.

PREFERRED SKILLS:

Experience in yeast display is a plus. Individuals with a passion for science and a capacity to work in a highly collaborative environment are encouraged to apply.

About the NCI Center for Cancer Research:

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply:

Submit:
  • CV/Resume
  • Three References
  • Cover Letter

Additional Application Information:

To apply, please send an e-mail with your CV, the names of three references, and a cover letter briefly describing your research experience and interests to Mitchell Ho, Ph.D.

Contact Name: Mitchell Ho

Contact Email: homi@mail.nih.gov

For questions contact: Mitchell Ho, homi@mail.nih.gov

HHS, NIH, and NCI are Equal Opportunity Employers