Brid M. Ryan, Ph.D., M.P.H.
Brid M. Ryan, Ph.D., M.P.H.
Investigator

Center for Cancer Research
National Cancer Institute

Building 37, Room 3060C
Bethesda, MD 20892
301-496-5886

Dr. Ryan was among the first to demonstrate asymmetric division of DNA in cancer. This process is thought to underpin how tumors self-renew and regenerate. Since then, her studies have examined the roles of the tumor microenvironment and p53 in regulating this process in lung cancer.

Her lab oversees an integrative and translational approach to lung cancer research, examining the genetic, environmental, and biological contributions to racial disparities in lung cancer incidence. Her research program also develops biomarkers for the early detection of lung cancer.

Areas of Expertise
1) Lung cancer 2) Asymmetric division 3) Molecular epidemiology 4) Health Disparities 5) Small non-coding RNAs 6) Cancer biomarkers

Our research program addresses several unanswered questions in lung cancer using an approach that integrates epidemiological, experimental and translational research. Disparities in lung cancer incidence, especially amongst men, have been evident for several decades. However, the potential etiological, genetic, and biological reasons behind these differences are underexplored and not well understood. Our laboratory investigates the science behind these health disparities and is using a multidisciplinary approach to address this question. Our laboratory is also interested in applying a biological framework to understanding the mechanism of interaction between genetics and environment with regard to lung carcinogenesis. Specifically, we have an interest in both early and adult life exposures and mechanistically understanding how they mediate lung cancer risk later in life.

Scientific Focus Areas:
Cancer Biology, Epidemiology, Health Disparities
  1. Ryan BM, Pine SS, Chaturvedi AK, Caporoso N, Harris CC.
    J Thoracic Oncol. 9: 1494-503, 2014. [ Journal Article ]
  2. Ryan BM, Wang Y, Jen J, Yi ES, Olivo-Marston S, Yang P, Harris CC.
    Cancer Epidemiol. Biomarkers Prev. 23: 1432-4, 2014. [ Journal Article ]
  3. Liu W, Jeganathan G, Amiri S, Morgan KM, Ryan BM, Pine SR.
    Mol. Cancer. 12: 139, 2013. [ Journal Article ]
  4. Pine SR, Ryan BM, Varticovski L, Robles AI, Harris CC.
    Proc. Natl. Acad. Sci. U.S.A. 107: 2195-200, 2010. [ Journal Article ]
  5. Ryan BM, Konecny GE, Kahlert S, Wang HJ, Untch M, Meng G, Pegram MD, Podratz KC, Crown J, Slamon DJ, Duffy MJ.
    Ann. Oncol. 17: 597-604, 2006. [ Journal Article ]

Dr. Ryan completed her undergraduate training in biochemistry at University College Cork, Ireland, in 2001. She received her Ph.D in Cancer Biology from University College Dublin and in 2006 was accepted into the NCI Cancer Prevention Fellowship Program. In 2007, she completed a Masters of Public Health at University College Dublin. She worked under the mentorship of Dr Curtis Harris during her postdoctoral training at the National Cancer Institute. In 2013, she became an NCI Earl Stadtman tenure track investigator at the NCI.

Name Position
Derek Brown M.Sc. Special Volunteer
Amy Flis Summer Student
Khadijah Mitchell M.Sc., Ph.D. Postdoctoral Fellow (CRTA)
Oscar Vidal M.Sc., Ph.D. Postdoctoral Fellow (Visiting)
Adriana Zingone M.D., Ph.D. Research Biologist

Summary

Dr. Ryan was among the first to demonstrate asymmetric division of DNA in cancer. This process is thought to underpin how tumors self-renew and regenerate. Since then, her studies have examined the roles of the tumor microenvironment and p53 in regulating this process in lung cancer.

Her lab oversees an integrative and translational approach to lung cancer research, examining the genetic, environmental, and biological contributions to racial disparities in lung cancer incidence. Her research program also develops biomarkers for the early detection of lung cancer.

Areas of Expertise
1) Lung cancer 2) Asymmetric division 3) Molecular epidemiology 4) Health Disparities 5) Small non-coding RNAs 6) Cancer biomarkers

Research

Our research program addresses several unanswered questions in lung cancer using an approach that integrates epidemiological, experimental and translational research. Disparities in lung cancer incidence, especially amongst men, have been evident for several decades. However, the potential etiological, genetic, and biological reasons behind these differences are underexplored and not well understood. Our laboratory investigates the science behind these health disparities and is using a multidisciplinary approach to address this question. Our laboratory is also interested in applying a biological framework to understanding the mechanism of interaction between genetics and environment with regard to lung carcinogenesis. Specifically, we have an interest in both early and adult life exposures and mechanistically understanding how they mediate lung cancer risk later in life.

Scientific Focus Areas:
Cancer Biology, Epidemiology, Health Disparities

Publications

  1. Ryan BM, Pine SS, Chaturvedi AK, Caporoso N, Harris CC.
    J Thoracic Oncol. 9: 1494-503, 2014. [ Journal Article ]
  2. Ryan BM, Wang Y, Jen J, Yi ES, Olivo-Marston S, Yang P, Harris CC.
    Cancer Epidemiol. Biomarkers Prev. 23: 1432-4, 2014. [ Journal Article ]
  3. Liu W, Jeganathan G, Amiri S, Morgan KM, Ryan BM, Pine SR.
    Mol. Cancer. 12: 139, 2013. [ Journal Article ]
  4. Pine SR, Ryan BM, Varticovski L, Robles AI, Harris CC.
    Proc. Natl. Acad. Sci. U.S.A. 107: 2195-200, 2010. [ Journal Article ]
  5. Ryan BM, Konecny GE, Kahlert S, Wang HJ, Untch M, Meng G, Pegram MD, Podratz KC, Crown J, Slamon DJ, Duffy MJ.
    Ann. Oncol. 17: 597-604, 2006. [ Journal Article ]

Biography

Dr. Ryan completed her undergraduate training in biochemistry at University College Cork, Ireland, in 2001. She received her Ph.D in Cancer Biology from University College Dublin and in 2006 was accepted into the NCI Cancer Prevention Fellowship Program. In 2007, she completed a Masters of Public Health at University College Dublin. She worked under the mentorship of Dr Curtis Harris during her postdoctoral training at the National Cancer Institute. In 2013, she became an NCI Earl Stadtman tenure track investigator at the NCI.

Team

Name Position
Derek Brown M.Sc. Special Volunteer
Amy Flis Summer Student
Khadijah Mitchell M.Sc., Ph.D. Postdoctoral Fellow (CRTA)
Oscar Vidal M.Sc., Ph.D. Postdoctoral Fellow (Visiting)
Adriana Zingone M.D., Ph.D. Research Biologist