Shree Ram Singh, Ph.D.

Shree Ram Singh, Ph.D.
Staff Scientist

Our current research is directed toward understanding the molecular genetic mechanism by which stem cells regulate tissue homeostasis, regeneration, and tumorigenesis. We are utilizing model organisms, cell lines and tissue systems to understand the above mechanisms. Specifically, we are using adult testis, kidney and gastrointestinal tissues to characterize the genes/signaling pathways that regulate stem cell behavior and tumor formation. Further, we are focusing on lipid metabolism (lipolysis) on stem cell fate. In collaboration with various scientists, we are also involved in screening of anti-cancer drugs, developing protocols in stem cell and modeling diseases, exploring the role of tumor-targeting bacteria in cancer therapy, metabolic pathways in stem cell and cancer, microRNA in stem cell regulation and aging, and precision medicine. 

Areas of Expertise

1) stem cells, 2) cancer, 3) cancer stem cells, 4) lipid metabolism, 5) cell death, 6) cell signaling, 7) anti-cancer drug screening, 8) tumor-targeting bacteria, 9) precision medicine

Contact Info

Shree Ram Singh, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 560, Room 12-70
Frederick, MD 21702-1201
Ph: 301-846-7331
singhshr@mail.nih.gov

Research

Stem cells are undifferentiated cells and play a critical role in tissue development, homeostasis, and regeneration. Stem cells self-renewal divisions are controlled by intrinsic and extrinsic factors. Failure of stem cells function in tissue maintenance results in degenerative diseases, on the other hand, the overproliferation of stem cells results in tumor development (Singh et al., Cell Research, 2005; Singh et al., Oncogene, 2006; Singh et al., Cell Stem Cell, 2007; Singh et al., Journal of Cellular and Molecular Medicine, 2011; SinghCurrent Medicinal Chemistry, 2012; SinghCancer Letters, 2013; Singh et al., Nature, 2016; Singh et al. Nature Communications, 2016;  Singh et al., Advances in Experimental Medicine and Biology, 2019). Our current research is directed toward understanding the molecular genetic mechanisms by which stem cells regulate tissue homeostasis, regeneration,  (Obara et al., Scientific Reports, 2019) and tumorigenesis. We are utilizing model organisms and various tissues and cell systems to understand the above mechanisms. We are also involved in cancer drug screening to identify novel regulators of regeneration, and cancer therapy (Choi et al., Cancer Letters, 2019), and exploring the role of tumor-targeting bacteria for cancer therapy (Igarashi et al., Translational Oncology, 2020). 

NIH Scientific Focus Areas:
Cancer Biology, Cell Biology, Developmental Biology, Genetics and Genomics, Stem Cell Biology
  1. Singh SR, Zeng X, Zhao J, Liu Y, Hou G, Liu H, Hou SX
    Nature. 538: 198-113, 2016. [ Journal Article ]
  2. Singh SR, Liu Y, Zhao J, Zeng X, Hou SX
    Nature Communications. 7: 10473, 2016. [ Journal Article ]
  3. Singh SR
    Cancer Letters. 338(1): 110-119, 2013. [ Journal Article ]
  4. Chan B, Manley J, Lee J, Singh SR
    Cancer Letters. 356: 301-308, 2015. [ Journal Article ]
  5. Singh SR, Liu W, Hou SX.
    Cell Stem Cell. 1: 191-203, 2007. [ Journal Article ]

Dr. Shree Ram Singh obtained his Ph.D. in genetics from the Department of Zoology, Banaras Hindu University, India in 2001. Dr. Singh was a guest scientist at the Department of Molecular Cell Biology Biocenter, Johann Wolfgang Goethe University, Frankfurt, Germany in 1998 and in 2001 he received a UNESCO Biotechnology Action Council (BAC) fellowship at the Department of Plant Molecular Biology Biocenter, Johann Wolfgang Goethe University. Dr. Singh pursued his postdoctoral research studies at the University of Haifa, Israel, and at the National Cancer Institute (NCI) at Frederick. Since 2011, he has served as a staff scientist at NCI Frederick. Dr. Singh was a Lead Guest Editor in 2012 for a special issue of Current Medicinal Chemistry on "Stem cells in Regenerative Medicine and Cancer", in 2013 for a special issue of Cancer Letters on "Cancer Stem Cells", in 2014 for a special issue of Frontiers in Bioscience on "Stem cell and Organogenesis", in 2015 for a special issue of Cancer Letters on "Cancer Metabolism", and in 2016 for a special issue of Cancer Letters on "Tumor Microenvironment". He publsihed 8 books. Dr. Singh is author and co-authors of more than 150 scientific papers published in several reputed journals including Nature, Cell Stem Cell, Developmental Cell, Nature Communications, Cell Reports, PLoS Genetics, and Oncogene.  

Paige Belt Werner H. Kirsten Student Program (WHK SIP) intern June 2019-December 2019
Cristopher Aguilar Ortiz The Werner H. Kirsten Student Intern Program (WHK SIP) June 2018 to August 2019
Alexis Fritts Capstone Fellow program of NCI-Frederick May 2019-August 2019
Beyonce Carrington Werner H. Kirsten Student Intern 2017-2018
Nathan Pinto Werner H. Kirsten Student Intern 2017-2018
Khushbu Jain Werner H. Kirsten Student Intern 2016-2017
Catharine Dietrich Werner H. Kirsten Student Intern 2016-2017
Makenzie Keepers Werner H. Kirsten Student Intern 2015-2016
Svati Kaushal Werner H. Kirsten Student Intern 2015-2016
Jae Eun Lee Werner H. Kirsten Student Intern 2014-2015
Jacob Manley Werner H. Kirsten Student Intern 2014-2015
Ann Marie K Weideman Summer Intern 2014
Brian Chan Post-Baccalaureate Fellow 2013-2015
Lyric Forney Werner H. Kirsten Student Intern 2013-2014
Lindsey Draper Summer Intern 2007, 2010