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Allan M. Weissman, M.D.

Allan M. Weissman, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Women's Malignancies Branch

RESEARCH SUMMARY

Allan Weissman is internationally recognized for pioneering work on the ubiquitin-proteasome system (UPS) and its roles in physiology and dysregulation in cancer and other diseases. The discovery by the Weissman lab of activation-dependent T cell antigen receptor ubiquitination made it one of the earliest characterized endogenous substrates for this covalent modification. Subsequently, Weissman and colleagues established RING finger proteins as the predominant family of ubiquitin ligases (E3s). This was followed by a string of other discoveries, some made in collaboration with CCR and extramural colleagues. 

Areas of Expertise

Molecular Mechanisms Of Cancer
Ubiquitin
Ubiquitin Ligases
Ubiquitin-Conjugating Enzymes
Deubiquitinating Enzymes
Endoplasmic Reticulum-Associated Degradation

Publications

Selected Recent Publications

SARS-CoV-2 papain-like protease plays multiple roles in regulating cellular proteins in the endoplasmic reticulum

Yang M, Mariano J, Su R, Smith CE, Das S, Gill C, Andressson, T, Loncarek J, Tsai YC, Weissman AM
Journal of Biological Chemistry. 299/12: doi: 10.1016/j.jbc.2023.105346, 2023.
Full-Text Article
[ Journal Article ]

Differential sensitivity of the yeast Lon protease Pim1p to impaired mitochondrial respiration

Metzger MB, Scales JL, Grant GA, Molnar AE, Loncarek J, Weissman AM
Journal of Biological Chemistry. 299/8: doi: 10.1016/j.jbc.2023.104937, 2023.
Full-Text Article
[ Journal Article ]

Protein expression of the gp78 E3 ligase predicts poor breast cancer outcome based on race

Singhal SK, Byun JS, Yan T, Yancey R, Caban A, Gil Hernandez S, Bufford S, Hewitt SM, Winfield J, Pradhan J, Mustkov V, McDonald JA, Pérez-Stable EJ, Nápoles AM, Vohra N, De Siervi A, Yates C, Davis MB, Yang M, Tsai YC, Weissman AM, Gardner K
JCI Insight. 7/13: 2022.
Full-Text Article

A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation

Smith CE, Tsai YC, Liang YH, Khago D, Mariano J, Li J, Tarasov SG, Gergel E, Tsai B, Villaneuva M, Clapp ME, Magidson V, Chari R, Byrd RA, Ji X, Weissman AM
PLos Biology. 19/12: doi: 10.1371/journal.pbio.3001474, 2021.
Full-Text Article
[ Journal Article ]

A protein quality control pathway at the mitochondrial outer membrane.

Metzger MB, Scales JL, Dunklebarger MF, Loncarek J, Weissman AM
eLife. 2/9: doi: 10.7554/eLife.51065, 2020.
Full-Text Article