Alla  Gustchina, Ph.D.
Alla Gustchina, Ph.D.
Staff Scientist

Center for Cancer Research
National Cancer Institute

Bldg. 539, Room 143
Frederick, MD 21702-1201
301-846-5338

My major research goal is to investigate structure-function relationship for a number of proteins, with particular emphasis on studies of aspartic proteases from mammals, parasites, and retroviruses. Other projects included studies of ATP-dependent protease Lon and serine-carboxyl proteases (sedolisins). I have been also involved in structural investigations of retroviral integrases.

Areas of Expertise
aspartic proteases

My major research goal is to investigate structure-function relationship for a number of proteins, with particular emphasis on studies of aspartic proteases from mammals, parasites, and retroviruses. Other projects included studies of ATP-dependent protease Lon and serine-carboxyl proteases (sedolisins). I have been also involved in structural investigations of retroviral integrases.

Selected Publications
  1. Zhang F, Walcott B, Zhou D, Gustchina A, Lasanajak Y, Smith DF, Ferreira RS, Correia MT, Paiva PM, Bovin NV, Wlodawer A, Oliva ML, Linhardt RJ.
    Biochemistry. 52: 2148-56, 2013. [ Journal Article ]
  2. Bhaumik P, Gustchina A, Wlodawer A.
    Biochim. Biophys. Acta. 1834: 207-223, 2012. [ Journal Article ]
  3. Gustchina E, Li M, Ghirlando R, Schuck P, Louis JM, Pierson J, Rao P, Subramaniam S, Gustchina A, Clore GM, Wlodawer A.
    PLoS ONE. 8: e78187, 2013. [ Journal Article ]
  4. Ferreira RD, Zhou D, Ferreira JG, Silva MC, Silva-Lucca RA, Mentele R, Paredes-Gamero EJ, Bertolin TC, Dos Santos Correia MT, Paiva PM, Gustchina A, Wlodawer A, Oliva ML.
    PLoS ONE. 8: e64426, 2013. [ Journal Article ]
  5. Zhou D, Lobo YA, Batista IF, Marques-Porto R, Gustchina A, Oliva ML, Wlodawer A.
    PLoS ONE. 8: e62252, 2013. [ Journal Article ]

Dr. Gustchina received her Ph. D. degree in 1984 at the Engelhardt Institute of Molecular Biology, Moscow, Russia. She worked there in the protein crystallography laboratory headed by Professor Natalia Andreeva. She joined the Macromolecular Crystallography Laboratory in 1989 and was appointed Staff Scientist in 1999.

Summary

My major research goal is to investigate structure-function relationship for a number of proteins, with particular emphasis on studies of aspartic proteases from mammals, parasites, and retroviruses. Other projects included studies of ATP-dependent protease Lon and serine-carboxyl proteases (sedolisins). I have been also involved in structural investigations of retroviral integrases.

Areas of Expertise
aspartic proteases

Research

My major research goal is to investigate structure-function relationship for a number of proteins, with particular emphasis on studies of aspartic proteases from mammals, parasites, and retroviruses. Other projects included studies of ATP-dependent protease Lon and serine-carboxyl proteases (sedolisins). I have been also involved in structural investigations of retroviral integrases.

Publications

Selected Publications
  1. Zhang F, Walcott B, Zhou D, Gustchina A, Lasanajak Y, Smith DF, Ferreira RS, Correia MT, Paiva PM, Bovin NV, Wlodawer A, Oliva ML, Linhardt RJ.
    Biochemistry. 52: 2148-56, 2013. [ Journal Article ]
  2. Bhaumik P, Gustchina A, Wlodawer A.
    Biochim. Biophys. Acta. 1834: 207-223, 2012. [ Journal Article ]
  3. Gustchina E, Li M, Ghirlando R, Schuck P, Louis JM, Pierson J, Rao P, Subramaniam S, Gustchina A, Clore GM, Wlodawer A.
    PLoS ONE. 8: e78187, 2013. [ Journal Article ]
  4. Ferreira RD, Zhou D, Ferreira JG, Silva MC, Silva-Lucca RA, Mentele R, Paredes-Gamero EJ, Bertolin TC, Dos Santos Correia MT, Paiva PM, Gustchina A, Wlodawer A, Oliva ML.
    PLoS ONE. 8: e64426, 2013. [ Journal Article ]
  5. Zhou D, Lobo YA, Batista IF, Marques-Porto R, Gustchina A, Oliva ML, Wlodawer A.
    PLoS ONE. 8: e62252, 2013. [ Journal Article ]

Biography

Dr. Gustchina received her Ph. D. degree in 1984 at the Engelhardt Institute of Molecular Biology, Moscow, Russia. She worked there in the protein crystallography laboratory headed by Professor Natalia Andreeva. She joined the Macromolecular Crystallography Laboratory in 1989 and was appointed Staff Scientist in 1999.