Robert Somerville, Ph.D.
The Cell Production Facility is responsible for the development of cellular products for protocol-driven adoptive cell transfer research in patients with advanced cancer. Additionally, we serve as a tissue biorepository to support ongoing Surgery Branch research efforts and an educational resource as adoptive cell transfer becomes a viable research modality for extramural research institutions.
The NCI Surgery Branch Cell Production Facility is charged with producing autologous cell products in support of our clinical trials. The majority of patients with advanced metastatic cancer now enrolled in clinical trials in the Surgery Branch have been failed by conventional medical care. The clinical protocols we support are testing critical hypotheses in the use of adoptive cell transfer for patients with metastatic melanoma and common epithelial cancers.
Selected Key Publications
- Science. 350(6266): 1387-1390, 2015. [ Journal Article ]
Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease.J. Clin Oncol.. 34(10): 1112-1121, 2016. [ Journal Article ]
Randomized selection design trial evaluating CD8+-enriched versus unselected tumor-infiltrating lymphocytes for adoptive cell therapy for patients with melanoma.J. Clin. Oncol.. 31(17): 2152-2159, 2013. [ Journal Article ]
Clinical scale rapid expansion of lymphocytes for adoptive cell transfer therapy in the WAVE® bioreactor.J Transl Med.. 10: 69, 2012. [ Journal Article ]
Simplified method of the growth of human tumor infiltrating lymphocytes in gas-permeable flasks to numbers needed for patient treatment.J Immunother.. 35(3): 283-292, 2012. [ Journal Article ]
|Rachel Beyer||Program Manager (Contr)|
|Carol Bryant||Laboratory Technician (Contr.)|
|Zulmarie Franco||Staff Biologist|
|Mary Ganges||Laboratory Technician (Contr.)|
|Michelle Langhan||Staff Biologist|
|Tangying Lu Ph.D.||Research Fellow|
|Azam Nahvi||Staff Biologist|
|Linda Parker||Technical Lab Manager|
|Thomas Shelton||Staff Biologist|
|Tyler Willett Ph.D.||Postdoctoral Fellow (CRTA)|
|John Wunderlich M.D.||Medical Officer|