Ping Zhang, Ph.D.

Ping Zhang, Ph.D.
Investigator
NIH Earl Stadtman Investigator

My laboratory studies the structural and mechanistic basis of kinases that are closely related to human cancers and many other diseases. Our main focus is on oncogenic kinases (including ALK, BRAF, Leucine Rich Repeat Kinase and PKA). We have also developed new collaborations within the CCR involving projects with propensity for translational application to the clinic, including the study of nucleosome complex and Microprocessor complex. We apply a combination of biochemical and structural (single-particle cryo-electron microscopy and X-ray crystallography) approaches to reveal the molecular mechanisms of such multi-component biological complexes and help to provide new strategies for therapeutic targeting.

Areas of Expertise
1) kinase, 2) cell signaling, 3) cancer biology, 4) structural biology

Contact Info

Ping Zhang, Ph.D.
Center for Cancer Research
National Cancer Institute
Advanced Technology Research Facility (ATRF), Room B2230
Frederick, MD 21701
Ph: 301-228-4092
ping.zhang@nih.gov

We apply interdisciplinary approaches spanning many fields such as cryoEM, X-ray crystallography, solution methods, biochemistry, and cell signaling, etc. We aim to combine structural and functional studies to reveal the molecular mechanism of kinase complexes' dysfunction and help develop novel reagents that may eventually lead to a cure for cancer and other diseases.

Scientific Focus Areas:
Biomedical Engineering and Biophysics, Cancer Biology, Molecular Biology and Biochemistry, Structural Biology
  1. Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg MH, and Taylor SS.
    Structure. 23(9): 1563-72, 2015. [ Journal Article ]
  2. Zhang P, Knape MJ, Ahuja L, Keshwani MM, King CC, Sastri M, Herberg FW, and Taylor, SS.
    PLoS Biol. 13(7): e1002192, 2015. [ Journal Article ]
  3. Taylor SS, Ilouz R, Zhang P, and Kornev, A.
    Nat Rev Mol Cell Biol. 13(10): 646-58, 2012. [ Journal Article ]
  4. Zhang P, Smith-Nguyen EV, Keshwani MM, Deal MS, Kornev AP, and Taylor SS.
    Science. 335(6069): 712-6, 2012. [ Journal Article ]
  5. Zhang P, Mueller S, Morais MC, Bator C, Bowman VD, Hafenstein S, Wimmer E, and Rossmann MG.
    Proc Natl Acad Sci U S A. 105(47): 18284-9, 2008. [ Journal Article ]

Dr. Zhang received her Ph.D. training in Dr. Michael Rossmann’s lab at Purdue University in the field of biochemistry and structural virology.  Her Ph.D. project was resolving the structures of poliovirus-receptor complexes using X-ray crystallography and cryo-electron microscopy (cryo-EM).  She completed her postdoctoral training in Dr. Susan Taylor’s laboratory at UCSD, working on a signal transduction system related to human diseases and learning other techniques in structural biology and cell signaling that are suited for studying dynamic signaling complexes. She joined the Structural Biophysics Laboratory at NCI as a Stadtman Tenure Track Investigator in August 2016.

Name Position
Baohua Cao Ph.D. Postdoctoral Fellow (Visiting)
Jeneffer England Ph.D. Postdoctoral Fellow (CRTA)
Juliana Andrea Martinez Fiesco Ph.D. Postdoctoral Fellow (Visiting)