News and Events
Cellular processing reverses molecule’s effect on anticancer immunity
Immune cells convert an immunosuppressive lipid into an anticancer immunity enhancer.
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Aligned Blog: The power of resilience in medicine: in conversation with Ramya Ramaswami, M.B.B.S., M.P.H.
In this latest issue of Aligned, Sonia Garcia, Ph.D., Scientific Diversity Program Manager, spoke to Ramya Ramaswami, M.B.B.S., M.P.H., Lasker Clinical Research Scholar in the HIV and AIDS Malignancy Branch, about her career, immigrating to the United States and the role resilience has played in her success.
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Clinical trial researching olfactory neuroblastoma
A clinical trial led by Charalampos S. Floudas, M.D., D.M.Sc., M.S., Assistant Research Physician in the Center for Immuno-Oncology, is researching the symptoms and characteristics of olfactory neuroblastoma.
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Novel T cell stimulation technique drives potent anti-tumor response
Researchers combined an antibody with an immune-signaling molecule resulting in an agent called STAR0602. A version of the novel agent was designed for and tested in mice, which induced significant tumor shrinkage and increased survival across six different types of cancer while exhibiting little toxicity. The promising lab findings have prompted the launch of a clinical trial in people.
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Experimental vaccine halts respiratory growths from HPV infection
An experimental vaccine that trains a patient’s immune system to recognize HPV-infected cells could potentially be used to treat people with recurrent respiratory papillomatosis, according to results from an ongoing clinical trial.
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Inactivating the WRN protein could kill colorectal and other cancer cells
Rapid inactivation of the Werner Syndrome helicase (WRN), a protein upon which cancer cells that exhibit microsatellite instability often rely for survival, could be effective in killing colorectal and other cancer cells and potentially guide the development of inhibitor drugs.
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In Memoriam: S. Perwez Hussain, Ph.D. (1960 - 2023)
The CCR community is profoundly saddened by the passing of S. Perwez Hussain, Ph.D., Senior Investigator in the Laboratory of Human Carcinogenesis. He died on November 24, 2023, after living with stage 4 colon cancer for many years.
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FDA grants orphan drug designation to indotecan for the treatment of glioma
The U.S. Food and Drug Administration (FDA) granted orphan drug status to LMP400 (indotecan) for use in patients with malignant glioma, a cancer of the brain that begins in glial cells (cells that surround and support nerve cells).
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Clinical trial researches combination drug therapy for myelodysplastic syndromes
A clinical trial led by Steven Z. Pavletic, M.D., Ph.D., Senior Clinician in the Immune Deficiency Cellular Therapy Program, is researching a combination drug therapy for myelodysplastic syndromes.
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Six years after preventive surgery: a patient’s future without stomach cancer
Faced with a high risk of developing stomach cancer, David Fogel chose to undergo preventive surgery as part of an NIH research study. Six years later, David is thriving, and so is the research that was made possible by his participation.
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Population-specific tumor mutation patterns may reflect breast cancer health disparities
African American, European American and Kenyan patients with breast cancer have different patterns of tumor mutations.
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