Karen A. Kurdziel, M.D.

Karen A. Kurdziel, M.D.
Staff Clinician
Staff Clinician

My research focuses on the use of imaging to improve cancer therapy development and to direct focal therapy; more specifically imaging radio-labeled drugs (radiotracers). We currently have a range of novel molecular imaging agents which target tumor specific receptors and/or physiologic processes intrinsic to tumors. Members of the Molecular Imaging Clinic work as a team to achieve its mission. My role involves the development, implementation and imaging data analysis of early phase translational imaging protocols or the integration of an imaging component into an existing clinical protocol.

Areas of Expertise
imaging

Contact Info

Karen A. Kurdziel, M.D.
Center for Cancer Research
National Cancer Institute
Building 10, Room B3B403
Bethesda, MD 20892-1088
Ph: 301-825-3656
kurdziek@mail.nih.gov

My research focuses on the use of imaging to improve cancer therapy development and to direct focal therapy; more specifically imaging radio-labeled drugs (radiotracers). We currently have a range of novel molecular imaging agents which target tumor specific receptors and/or physiologic processes intrinsic to tumors. Members of the Molecular Imaging Clinic work as a team to achieve its mission. My role involves the development, implementation and imaging data analysis of early phase translational imaging protocols or the integration of an imaging component into an existing clinical protocol. When indicated, data from the clinical trials is fed back into the pre-clinical/ basic science venue to ensure target validation. Imaging can be most effective in supporting oncology drug development if the parameter measured are accepted by the FDA as validated biomarkers. In working towards the development of such quantitative imaging bio-markers, our data analysis involves both visual and quantitative methods, comparison of methodologies amongst each other as well as with pathology and clinical outcomes.

We collaborate with the NCI Cancer Imaging Program's (CIP) Quantitative Imaging Network (QIN) and the National Institute of Standards and Technology (NIST) in this work. Imaging agents currently in early phase imaging trials are listed on the MIP website

Selected Publications

  1. The Kinetics and Reproducibility of 18F-Sodium Fluoride for Oncology Using Current PET Camera Technology.
    Karen A. Kurdziel, Joanna H. Shih, Andrea B. Apolo, Liza Lindenberg, Esther Mena, Yolanda Y. McKinney, Stephen S. Adler, Baris Turkbey, William Dahut, James L. Gulley, Ravi A. Madan, Ola Landgren, and Peter L. Choyke
    J Nucl Med. 53: 1175-1184, 2012. [ Journal Article ]
  2. Mena E, Turkbey B, Mani H, Adler S, Valera VA, Bernardo M, Shah V, Pohida T, McKinney Y, Kwarteng G, Daar D, Lindenberg ML, Eclarinal P, Wade R, Linehan WM, Merino MJ, Pinto PA, Choyke PL, Kurdziel KA.
    J. Nucl. Med.. 53: 538-45, 2012. [ Journal Article ]
  3. Targeting MDR in breast and lung cancer: Discriminating its potential importance from the failure of drug resistance reversal studies.
    Laleh Amiri-Kordestani, Agnes Basseville, Karen Kurdziel, Antonio Tito Fojo, Susan E. Bates
    Drug Resistance Updates . 15: 50-61, 2012. [ Journal Article ]
  4. Human Dosimetry and Preliminary Tumor Distribution of 18F-Fluoropaclitaxel in Healthy Volunteers and Newly Diagnosed Breast Cancer Patients Using PET/CT.
    Karen A. Kurdziel, Joseph D. Kalen, Jerry I. Hirsch, John D. Wilson, Harry D. Bear, Jean Logan, James McCumisky, Kathy Moorman-Sykes, Stephen Adler, and Peter L. Choyke
    J Nucl Med. 52: 1339-1345, 2011. [ Journal Article ]
  5. Localized prostate cancer detection with 18F FACBC PET/CT: comparison with MR imaging and histopathologic analysis.
    Turkbey B, Mena E, Shih J, Pinto PA, Merino MJ, Lindenberg ML, Bernardo M, McKinney YL, Adler S, Owenius R, Choyke PL, Kurdziel KA.
    Radiology. 270: 849-56, 2014. [ Journal Article ]

Karen Kurdziel, M.D. joined the Molecular Imaging Program (MIP) from Virginia Commonwealth University (VCU)/ Medical College of Virginia where she was the Medical Director for the VCU Molecular Imaging Center. She is a board-certified nuclear medicine physician, alumnus of the NIH Imaging Sciences Training Program, with extensive skills in experimental nuclear medicine imaging and translational imaging.