Ulrike Boehm, Ph.D.

Ulrike Boehm, Ph.D.
Postdoctoral Fellow (Visiting)

Team Member of:

Dr. Ulrike Boehm explores how gene expression in living cells works using, developing and combining new technologies.

Areas of Expertise
1) advanced optical imaging 2) super-resolution microscopy 3) single-molecule biophysics & imaging 4) gene expression 5) transcription

Contact Info

Ulrike Boehm, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 41, Room B303
Bethesda, MD 20892
Ph: 240-760-6581 (office)
240-760-6686 (lab)
Fax: 240-541-4450
ulrike.boehm@nih.gov

Dr. Ulrike Boehm seeks to understand the control of gene expression in eukaryotic cells which requires the understanding of the 3D organization of the genome. So far, it is not well understood how the genome is organized in the 3D environment of the nucleus to promote the correct interactions and avoid potentially deleterious ones or what mechanisms regulate this organization.

Dr. Ulrike Boehm is engaged in using, developing and combining new technologies to enable this research, including:

1. super-resolution microscopy
2. single molecule imaging
3. genetic engineering
4. next generation sequencing approaches
5. mathematical and biophysical modeling

Scientific Focus Areas:
Biomedical Engineering and Biophysics, Chromosome Biology, Genetics and Genomics, Systems Biology

Selected Key Publications

  1. Boehm U, Hell SW, and Schmidt R.
    Nat Commun. 7(10504): 1-8, 2016. [ Journal Article ]
  2. Flexible microdomain specific staining of block copolymers for 3D optical nanoscopy.
    Ullal CK, Primpke S, Schmidt R, Boehm U, Egner A, Vana P, and Hell SW.
    Macromolecules. 44(19): 7508–7510, 2011. [ Journal Article ]
  3. Rigort A, Bäuerlein FJ, Leis A, Gruska M, Hoffmann C, Laugks T, Boehm U, Eibauer M, Gnaegi H, Baumeister W, and Plitzko JM
    J Struct Biol. 172(2): 169-79, 2010. [ Journal Article ]

Ulrike Boehm, Ph.D., studied physics at the Technical University of Munich (2004-2009). Her undergraduate research included several internships at various research institutions in Germany. Ulrike’s educational program was completed magna cum laude with a research project on correlative microscopy at liquid nitrogen temperature in the group of Wolfgang Baumeister at the Max Planck Institute for Biochemistry, Martinsried/Munich, Germany.

She performed her Ph.D. research in the group of Nobel Laureate Stefan Hell at the Max Planck Institute for Biophysical Chemistry, Goettingen, Germany. In Goettingen she developed a new super-resolution technique for the three-dimensional visualization of living biological structures and their dynamics at low light levels. She successfully defended her thesis titled, “4Pi-RESOLFT nanoscopy” magna cum laude in 2016 at the University of Heidelberg.

Since 2016, Ulrike works as a postdoctoral fellow at the Center for Cancer Research, National Cancer Institute, National Institute of Health in Bethesda, Maryland, USA, broadening her imaging and scientific skills. Using single-molecule imaging, super-resolution microscopy and various biophysical and molecular approaches she will explore how gene expression in living cells works.