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Jadranka  Loncarek, Ph.D.

Jadranka Loncarek, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Cancer Innovation Laboratory

RESEARCH SUMMARY

Dr. Loncarek studies the fundamentals of centrosome biology. Centrosomes are cellular organelles that mediate vital cellular processes such as cell division, signaling, motility, and development. Centrosome aberrations are a hallmark of tumors and cilia-related diseases. Her lab aims to elucidate how centrosome biogenesis is controlled and coordinated with other cell cycle events in healthy and pathological conditions and how centrosomes organize in nanoscale resolution. She combines molecular biology, biochemistry, and genetics with cutting-edge microscopy approaches such as super-resolution microscopy and correlative light and electron microscopy.

Areas of Expertise

Centrosome
Centriole
Cell Cycle
Super Resolution Microscopy
Transmission Electron Microscopy

Publications

Selected Publications

CPAP insufficiency leads to incomplete centrioles that duplicate but fragment.

Vásquez-Limeta A; Lukasik K; Kong D; Sullenberger C; Luvsanjav D; Sahabandu N; Chari R; Loncarek J
J. Cell Biol. . 2022. [ Journal Article ]

Prolonged mitosis results in structurally aberrant and over-elongated centrioles

Kong D, Sahabandu N, Sullenberger C, Vásquez-Limeta A, Luvsanjav D, Lukasik K, Loncarek J
J Cell Biol. 219(6): 2020. [ Journal Article ]

High-resolution characterization of centriole distal appendage morphology and dynamics by correlative STORM and electron microscopy

Bowler M, Kong D, Sun S, Nanjundappa R, Evans L, Farmer V, Holland A, Mahjoub MR, Sui H, Loncarek J
Nat Commun . Mar 1; 10 (1): 993, 2019. [ Journal Article ]

Centriole maturation requires regulated Plk1 activity during two consecutive cell cycles

Kong D, Farmer V, Shukla A, James J, Gruskin R, Kiriyama S, Loncarek J
J Cell Biol. 206(7): 855-65, 2014. [ Journal Article ]

Control of daughter centriole formation by the pericentriolar material

Loncarek J, Hergert P, Magidson V, Khodjakov A
Nat Cell Biol. 10(3): 322-8, 2008. [ Journal Article ]

Team

Staff Scientist
Dong Kong, Ph.D.
Scientist II (Contr.)
Delgermaa Luvsanjav, Ph.D.
POSTDOCTORAL VISITING FELLOW
Sanjay Kumar, Ph.D.

Alumni

Alejandra Vasquez-Limeta
Alejandra Vasquez-Limeta
2016-2023
Postodtral Fellow
Catherine Sullenberger
Catherine Sullenberger
2017-2023
Postodtral Fellow
Pegah Avazpour
Pegah Avazpour
20121-2023
Postbac
Thomas Janas
Thomas Janas
2021-2022
Postbac
Nicholas Werner
Nicholas Werner
2020-2021
Postbac
Kimberly Lukasik
Kimberly Lukasik
2018-2020
Postbac
Natalie Sahabandu
Natalie Sahabandu
2018-2019
Postbac
Matthew Bowler
Matthew Bowler
2016-2018
Postbac
Susan Dang
Susan Dang
2017-2018
Postbac
Ovais Hasan
Ovais Hasan
2018
Summer student
Kristina Cronise
Kristina Cronise
2016-2017
Postbac
Sylvana Aho
Sylvana Aho
2017
Summer student
Veronica Farmer
Veronica Farmer
2012, 2013-2015
Summer student and Postbac
Meena Sharma
Meena Sharma
2013-2016
Postbac
Anil Shukla
Anil Shukla
2012-2016
Postdoctoral fellow
Sett Naing
Sett Naing
2015
Summer student
Vignesh Rajasekaran
Vignesh Rajasekaran
2015
Summer student
Amil Sahai
Amil Sahai
2014
Summer student
Jana James
Jana James
2012-2013
Postbac
Dong Kong
Dong Kong
2012 - 1017 postdoctoral fellow and 2017- present: Staff Scientist
Postdoctoral fellow