Kenneth Aldape, M.D.

Kenneth Aldape, M.D.
Chief
Senior Investigator

Dr. Aldape is a molecular neuropathologist with a focus on the molecular basis and classification of brain tumors.  From a broader perspective, he is interested in the use of new technologies (genomic, computational) that contribute to precision diagnostics of cancer, and ultimately improved patient outcomes.

Areas of Expertise
1) molecular genomics of brain tumors 2) diagnostic neuropathology 3) precision diagnostics 4) epigenomic signatures of cancer

Contact Info

Kenneth Aldape, M.D.
Center for Cancer Research
National Cancer Institute
Building 10, Room 2S235
Bethesda, MD 20892-1500
Ph: 301-480-5010
kenneth.aldape@nih.gov

My laboratory studies genomic and epigenomic alterations in brain tumors, including glioma and meningioma.  We characterize the biology of specific genomic alterations and how they contribute to the molecular pathogenesis and treatment resistance of aggressive brain tumors.  We also utilize genomic signatures with a goal of identifying clinically relevant subclasses.  Our hypothesis is that biologically-based classification of brain tumors will lead to a greater understanding of why specific tumor subtypes may be more or less sensitive to therapeutics.

At the branch level, and as a diagnostic pathologist, I am passionate about the use of new technologies to improve diagnostics of cancer.  Morphologic interpretation by the light microscope is an extremely effective tool for classification, but can be limited by subjectivity and ambiguity for difficult-to-diagnse cases.  The increasing application of genomic, epigenomic and computational modalities show promise to improve precision and accuracy of cancer diagnostics.  The future of diagnostic pathology will increasingly utilize genetic and epigenomic alterations, as well as computational and image analysis approaches to define and classify cancer.  My vision is to disrupt our current practice of sole reliance on morphologic interpretation by integrating these and other technologies within our current standard of care to promote precision diagnostics of cancer.

Scientific Focus Areas:
Cancer Biology, Genetics and Genomics
View Dr. Aldape's PubMed Summary.

Selected Key Publications

  1. Phillips HS, Kharbanda S, Chen R, Forrest WF, Soriano RH, Wu TD, Misra A, Nigro JM, Colman H, Soroceanu L, Williams PM, Modrusan Z, Feuerstein BG, Aldape K.
    Cancer Cell. 9(3): 157-173, 2006. [ Journal Article ]
  2. Noushmehr H, Weisenberger DJ, Diefes K, Phillips HS, Pujara K, Berman BP, Pan F, Pelloski CE, Sulman EP, Bhat KP, Verhaak RG, Hoadley KA, Hayes DN, Perou CM, Schmidt HK, Ding L, Wilson RK, Van Den Berg D, Shen H, Bengtsson H, Neuvial P, Cope LM, Buckley J, Herman JG, Baylin SB, Laird PW, Aldape K; Cancer Genome Atlas Research Network.
    Cancer Cell. 17(5): 510-522, 2010. [ Journal Article ]
  3. Bhat KPL, Balasubramaniyan V, Vaillant B, Ezhilarasan R, Hummelink K, Hollingsworth F, Wani K, Heathcock L, James JD, Goodman LD, Conroy S, Long L, Lelic N, Wang S, Gumin J, Raj D, Kodama Y, Raghunathan A, Olar A, Joshi K, Pelloski CE, Heimberger A, Kim SH, Cahill DP, Rao G, Den Dunnen WFA, Boddeke HW, Phillips HS, Nakano I, Lang FF, Colman H, Sulman EP, Aldape K.
    Cancer Cell. 24(3): 331-46, 2013. [ Journal Article ]
  4. Agnihotri S, Suppiah S, Tonge PD, Jalali S, Danesh A, Bruce JP, Mamatjan Y, Klironomos G, Gonen L, Au K, Mansouri S, Karimi S, Sahm F, von Deimling A, Taylor MD, Laperriere NJ, Pugh TJ, Aldape KD*, Zadeh G*. *co-corresponding author
    Nature Communications. 8(1): 186, 2017. [ Journal Article ]
  5. Agnihotri S, Jalali S, Wilson MR, Danesh A, Li M, Klironomos G, Krieger JR, Mansouri A, Khan O, Mamatjan Y, Landon-Brace N, Tung T, Dowar M, Li T, Bruce JP, Burrell KE, Tonge PD, Alamsahebpour A, Krischek B, Agarwalla PK, Bi WL, Dunn IF, Beroukhim R, Fehlings MG, Bril V, Pagnotta SM, Iavarone A, Pugh TJ, Aldape KD*, Zadeh G*. *co-corresponding author
    Nature Genetics. 48(11): 1339-1348, 2016. [ Journal Article ]

Dr. Aldape is a diagnostic and molecular neuropathologist who focusses on genomics and molecular pathogenesis of primary brain tumors.  He studies the biology of specific alterations in brain tumors, including the CIC tumor suppressor gene.   As a diagnostic pathologist, he works on the integration of new genomic and computational approaches to improve how cancer can be classified and treated.  The future of cancer classification and treatment decisions will increasingly integrate these tools into clinical practice, and his vision is to contribute to this new paradigm in pathology. Previously, Dr. Aldape has held faculty positions at the University of California, San Francisco, MD Anderson Cancer Center and Princess Margaret Cancer Centre. 

Position Number of Positions Contact E-mail Contact Name Contact Phone
Staff Scientist (Bioinformatics) 1 hostlers@mail.nih.gov Susan Hostler 301-480-6286