Shannon M. Doyle, Ph.D.

Team Member of:
The Wickner lab is focused on understanding the mechanisms of ATP dependent molecular chaperones. One specific aim is to understand the role of the molecular chaperone ClpB in protein disaggregation and remodeling. We are interested in determining the biochemical mechanism of action for ClpB as well as understanding how ClpB collaborates with other chaperones, such as DnaK, in protein disaggregation.
molecular chaperones
Contact Info
Center for Cancer Research
National Cancer Institute
Building 37, Room 5144
Bethesda, MD 20892-4263
Ph: 240-760-7836
doyles@mail.nih.gov
The Wickner lab is focused on understanding the mechanisms of ATP dependent molecular chaperones. One specific aim is to understand the role of the molecular chaperone ClpB in protein disaggregation and remodeling. We are interested in determining the biochemical mechanism of action for ClpB as well as understanding how ClpB collaborates with other chaperones, such as DnaK, in protein disaggregation.
Selected Publications
- J. Biol. Chem.. 287: 28470-9, 2012. [ Journal Article ]
- Proteins. 80: 2758-68, 2012. [ Journal Article ]
- Prion. 5: 2011. [ Journal Article ]
- Proceedings of the National Academy of Sciences of the United States of America. 2011. [ Journal Article ]
- Nat. Rev. Mol. Cell Biol.. 14: 617-29, 2013. [ Journal Article ]
Shannon Doyle did her undergraduate work in Microbiology at Michigan State University. She completed her Ph.D. in Biochemistry at the University of Connecticut in the lab of Dr. Carolyn M. Teschke. She continued as a postdoctoral fellow and then research fellow with Dr. Sue Wickner in the Laboratory of Molecular Biology in the National Cancer Institute prior to becoming the lab staff scientist.