Brid M. Ryan, Ph.D., M.P.H.

Brid M. Ryan, Ph.D., M.P.H.
Investigator
NIH Stadtman Investigator

Dr. Ryan was among the first to demonstrate asymmetric division of DNA in cancer. This process is thought to underpin how tumors self-renew and regenerate. Since then, her studies have examined the roles of the tumor microenvironment and p53 in regulating this process in lung cancer.

Her lab oversees an integrative and translational approach to lung cancer research, examining the genetic, environmental, and biological contributions to racial disparities in lung cancer incidence. Her research program also develops biomarkers for the early detection of lung cancer.

Areas of Expertise
1) Lung cancer 2) Asymmetric division 3) Molecular epidemiology 4) Health Disparities 5) Small non-coding RNAs 6) Cancer biomarkers

Contact Info

Brid M. Ryan, Ph.D., M.P.H.
Center for Cancer Research
National Cancer Institute
Building 37, Room 3060C
Bethesda, MD 20892
Ph: 240-760-6849
Brid_Ryan@nih.gov

Our research program addresses several unanswered questions in lung cancer using an approach that integrates epidemiological, experimental and translational research. Disparities in lung cancer incidence, especially amongst men, have been evident for several decades. However, the potential etiological, genetic, and biological reasons behind these differences are underexplored and not well understood. Our laboratory investigates the science behind these health disparities and is using a multidisciplinary approach to address this question. Our laboratory is also interested in applying a biological framework to understanding the mechanism of interaction between genetics and environment with regard to lung carcinogenesis. Specifically, we have an interest in both early and adult life exposures and mechanistically understanding how they mediate lung cancer risk later in life.

Scientific Focus Areas:
Cancer Biology, Epidemiology, Health Disparities
  1. Ryan BM
    Carcinogenesis. May 28;39(6): 741-751, 2018. [ Journal Article ]
  2. Erickson P, Gardner LD, Loffredo CA, St George DM, Bowman ED, Deepak J, Mitchell K, Meaney CL, Langenberg P, Bernat DH, Amr S, Ryan BM.
    Cancer Epidemiol Biomarkers Prev. Aug 31. doi: 10.1158/1055-9965: 2018.
  3. Mitchell KA, Zingone A, Toulabi L, Boeckelman J, Ryan BM.
    Clin Cancer Res. Dec 1;23(23): 7412-7425, 2017. [ Journal Article ]
  4. Robles AI, Yang P, Jen J, McClary AC, Calhoun K, Bowman ED, Vähäkangas K, Greathouse KL, Wang Y, Olivo-Marston S, Wenzlaff AS, Deng B, Schwartz AG, Ryan BM.
    Cancer Prev Res . Dec;7(12):: 1210-8, 2014. [ Journal Article ]
  5. Pine SR, Ryan BM, Varticovski L, Robles AI, Harris CC.
    Proc. Natl. Acad. Sci. U.S.A. 107: 2195-200, 2010. [ Journal Article ]

Dr. Ryan completed her undergraduate training in biochemistry at University College Cork, Ireland, in 2001. She received her Ph.D in Cancer Biology from University College Dublin and in 2005 was accepted into the NCI Cancer Prevention Fellowship Program. In 2007, she completed a Masters of Public Health at University College Dublin. She worked under the mentorship of Dr Curtis Harris during her postdoctoral training at the National Cancer Institute. In 2013, she became an NCI Earl Stadtman tenure track investigator at the NCI.

Name Position
Rony Arauz Melendez Ph.D. Postdoctoral Fellow (iCURE)
Christopher E. Grant MSc. Predoctoral Fellow (Graduate Student)
Emily Rossi Ph.D., MPH Postdoctoral Fellow (CPFP)
Sanju Sinha B.S. Predoctoral Fellow (Graduate Student)
Leila Toulabi Ph.D. Postdoctoral Fellow (CRTA)
Adriana Zingone M.D., Ph.D. Biologist