Dr. Robles' complete bibliography in PUBMED
Ana I. Robles, Ph.D.
My research interests include the bioinformatics analysis of microRNA and mRNA expression as it relates to lung cancer, cancer susceptibility syndromes and senescence, the effect of genetic variation on microRNA-mediated regulatory pathways, as well as the identification of lung cancer progenitor cells.
Our research focuses on omics-based identification and functional characterization of clinically informative biomarkers of lung cancer. Our studies leverage the integrative analysis of genomic, epigenomic and transcriptomic data of well-characterized patient populations to uncover biomarkers that aid patient stratification into risk categories, and generate hypothesis that illuminate biology. As part of this effort, we are exploring DNA methylation biomarkers for diagnosis and prognosis of lung cancer utilizing droplet digital PCR. Following up on evidence from 16S rRNA and metagenomics sequencing indicating that specific bacteria are associated with the development of lung cancer in humans, we are investigating the role of the microbiome in lung cancer development using a transgenic mouse model conditionally expressing oncogenic Kras and a gain-of-function mutant p53 (a combination of mutations commonly found in human lung cancer) exposed to selected bacterial strains.
- Gastroenterology. 150: 931-43, 2016. [ Journal Article ]
An Integrated Prognostic Classifier for Stage I Lung Adenocarcinoma Based on mRNA, microRNA, and DNA Methylation Biomarkers.J Thorac Oncol.. 10: 1037-48, 2015. [ Journal Article ]
- N Engl J Med. 376: 2190-1, 2017. [ Journal Article ]
- Lung Cancer. 107: 50-8, 2017. [ Journal Article ]
- Transl Lung Cancer Res. 5: 492-504, 2016. [ Journal Article ]
Dr. Ana I. Robles received her Ph.D. degree from the Graduate School of Biomedical Sciences, University of Texas, for research done on mouse skin carcinogenesis under the mentorship of Dr. Claudio Conti, at the M.D. Anderson Cancer Center. She joined the Laboratory of Human Carcinogenesis as a postdoctoral fellow in 1996, and became a Staff Scientist in 2004.