Yaakov Maman, Ph.D.
Dr. Maman is a computational biologist with a primary interest in understanding genome integrity and chromatin structure in the context of the Immune system. During the past 4 years Dr. Maman has studied the mechanism of targeting of the central DNA editors used by the immune system to build the diverse immune repertoire–RAG and AID, and made an important contribution to the fields of genomics and immunology.
Currently, Dr. Maman takes advantage of a sophisticated technique designed in the Lab to identify DNA double-stranded breaks to more generally understand the contribution of the chromatin structure and transcriptional activity to genome integrity.
Dr. Maman takes advantage of a sophisticated technique designed in the Lab to identify DNA double-stranded breaks to more generally understand the contribution of the chromatin structure and transcriptional activity to genome integrity.
Selected Key Publications
RAG1 targeting in the genome is dominated by chromatin interactions mediated by the non-core regions of RAG1 and RAG2.Nucleic Acids Res. 44(20): 9624-9637, 2016. [ Journal Article ]
- Cell. 162(4): 751–765, 2015. [ Journal Article ]
Evolutionary Principles In Viral Epitopes.In: Mathematical Methods and Models in Biomedicine. Springer 59-83, 2013. [ Book Chapter ]
Bacteria modulate the CD8+ T cell epitope repertoire of host cytosol-exposed proteins to manipulate the host immune response.PLoS Comput Biol. 7(10): e1002220, 2011. [ Journal Article ]
Immune-induced evolutionary selection focused on a single reading frame in overlapping hepatitis B virus proteins.J Virol. 85(9): 4558-4566, 2011. [ Journal Article ]
Dr. Maman received both his bachelor and master's degrees in biology from Ben-Guryon University, Israel, and his Ph.D. from Bar-Ilan University, Israel. He continued his postdoctoral training at Yale Schools of Medicine, in the laboratory of Prof. David Schatz, where he investigated the mechanism of targeting of RAG and AID proteins to antigen receptor loci of lymphocytes. In 2016, he joined the Laboratory of Genome Integrity in the Center for Cancer Research, NCI, NIH, where he investigates the role of chromatin structure and transcription in genome integrity.