Yaakov Maman, Ph.D.

Staff Scientist

Team Member of:

Dr. Maman is a computational biologist with a primary interest in understanding genome integrity and chromatin structure in the context of the Immune system. During the past 4 years Dr. Maman has studied the mechanism of targeting of the central DNA editors used by the immune system to build the diverse immune repertoire–RAG and AID, and made an important contribution to the fields of genomics and immunology.

Currently, Dr. Maman takes advantage of a sophisticated technique designed in the Lab to identify DNA double-stranded breaks to more generally understand the contribution of the chromatin structure and transcriptional activity to genome integrity.

Areas of Expertise
1) bioinformatics 2) genomics 3) immunology 4) chromatin

Contact Info

Yaakov Maman, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 37 Room 1118B
Bethesda, MD 20892-4254
Ph: 240-760-7606
Fax: 240-541-4489
yaakov.maman@nih.gov

Dr. Maman takes advantage of a sophisticated technique designed in the Lab to identify DNA double-stranded breaks to more generally understand the contribution of the chromatin structure and transcriptional activity to genome integrity.

Scientific Focus Areas:
Computational Biology, Genetics and Genomics, Immunology

Selected Key Publications

  1. Maman Y, Teng G, Seth R, Kleinstein SH, and Schatz DG.
    Nucleic Acids Res. 44(20): 9624-9637, 2016. [ Journal Article ]
  2. Teng G, Maman Y, Resch W, Kim M, Yamane A, Qian J, Kieffer-Kwon KR, Manda M, Ji Y, Meffre E, Clark MR, Cowell LG, Casellas R, and Schatz, DG.
    Cell. 162(4): 751–765, 2015. [ Journal Article ]
  3. Evolutionary Principles In Viral Epitopes.
    Maman Y, Agranovich A, Vider-Shalit T, and Louzoun Y.
    In: Mathematical Methods and Models in Biomedicine. Springer 59-83, 2013. [ Book Chapter ]
  4. Maman Y, Nir-Paz R, and Louzoun, Y.
    PLoS Comput Biol. 7(10): e1002220, 2011. [ Journal Article ]
  5. Maman Y, Blancher A, Benichou J, Yablonka A, Efroni S, and Louzoun Y.
    J Virol. 85(9): 4558-4566, 2011. [ Journal Article ]

Dr. Maman received both his bachelor and master's degrees in biology from Ben-Guryon University, Israel, and his Ph.D. from Bar-Ilan University, Israel. He continued his postdoctoral training at Yale Schools of Medicine, in the laboratory of Prof. David Schatz, where he investigated the mechanism of targeting of RAG and AID proteins to antigen receptor loci of lymphocytes. In 2016, he joined the Laboratory of Genome Integrity in the Center for Cancer Research, NCI, NIH, where he investigates the role of chromatin structure and transcription in genome integrity.