Laboratory of Genitourinary Cancer Pathogenesis

Chief
Kathleen Kelly Siebenlist, Ph.D.

LGCP Branch PhotoThe Laboratory of Genitourinary Cancer Pathogenesis (LGCP) focuses on genitourinary (GU) cancers, especially prostate cancer, with the goal of understanding fundamental processes of cancer pathogenesis and translating this knowledge into clinical applications. We work within the Urologic Oncology Collaborative Group, which brings together integrated basic and translational research, surgical oncology, and medical oncology for the purpose of improving the detection, diagnosis, and treatment of patients with GU cancers. Specifically, LGCP includes mechanism-oriented research programs to investigate 1) the action of common prostate cancer genomic mutations, 2) microenvironmental influences on tumor progression and metastasis development, 3) castration resistance and prostate cancer stem cells, and 4) the regulation of responses to cell death pathways.


There are no Open Positions at this time, check back again later.


The Laboratory of Genitourinary Cancer Pathogenesis (LGCP) Microscopy Core provides training, guidance, and state-of-the-art service to LCGP scientists as well as other NCI-CCR researchers who require in vivo imaging or confocal microscopy techniques as part of their research efforts.

The LGCP Microscopy Core currently houses:

  • A Carl Zeiss LSM 780 laser scanning confocal microscope equipped with two PMTs and one 32 channel GaAsP spectral detector.
  • An Olympus VivaView fluorescence incubator microscope for long-term live cell imaging
  • Two Zeiss AxioObserver.Z1 epifluorescent scopes equipped with a digital camera and Zen software.
  • A Zeiss AxioScan.Z1 slide scanner capable of imaging fluorescent or brightfield slides

Please visit the LGCP Microscopy Core website for more information about our instrumentation, policies, software, techniques, publications, and how to access services. Image acquisition and analysis is provided free of charge.

Scientists who are fully trained in confocal microscopy work independently while inexperienced users are encouraged to arrange for training or to establish a collaboration with Ross Lake.

The LGCP Seminar Series runs from August to May.

Seminars are every Thursday from 2-3PM in the 4th Floor Conferance Room of Building 37
 

 

 

About

LGCP Branch PhotoThe Laboratory of Genitourinary Cancer Pathogenesis (LGCP) focuses on genitourinary (GU) cancers, especially prostate cancer, with the goal of understanding fundamental processes of cancer pathogenesis and translating this knowledge into clinical applications. We work within the Urologic Oncology Collaborative Group, which brings together integrated basic and translational research, surgical oncology, and medical oncology for the purpose of improving the detection, diagnosis, and treatment of patients with GU cancers. Specifically, LGCP includes mechanism-oriented research programs to investigate 1) the action of common prostate cancer genomic mutations, 2) microenvironmental influences on tumor progression and metastasis development, 3) castration resistance and prostate cancer stem cells, and 4) the regulation of responses to cell death pathways.

PI & Key Staff

Positions


There are no Open Positions at this time, check back again later.


Cores

The Laboratory of Genitourinary Cancer Pathogenesis (LGCP) Microscopy Core provides training, guidance, and state-of-the-art service to LCGP scientists as well as other NCI-CCR researchers who require in vivo imaging or confocal microscopy techniques as part of their research efforts.

The LGCP Microscopy Core currently houses:

  • A Carl Zeiss LSM 780 laser scanning confocal microscope equipped with two PMTs and one 32 channel GaAsP spectral detector.
  • An Olympus VivaView fluorescence incubator microscope for long-term live cell imaging
  • Two Zeiss AxioObserver.Z1 epifluorescent scopes equipped with a digital camera and Zen software.
  • A Zeiss AxioScan.Z1 slide scanner capable of imaging fluorescent or brightfield slides

Please visit the LGCP Microscopy Core website for more information about our instrumentation, policies, software, techniques, publications, and how to access services. Image acquisition and analysis is provided free of charge.

Scientists who are fully trained in confocal microscopy work independently while inexperienced users are encouraged to arrange for training or to establish a collaboration with Ross Lake.

Contact Info

Laboratory of Genitourinary Cancer Pathogenesis
Center for Cancer Research
National Cancer Institute
Building 37, Room 1068
Bethesda, MD 20892-4263
Ph: 301-435-4651
Administrative Lab Manager
301-435-4652
Technical Lab Manager
301-402-4869