Ross Lake is the head of the Laboratory of Genitourinary Cancer Pathogenesis (LCGP) Microscopy Core Facility, which provides state-of-the-art equipment, materials, and expertise to researchers in the LGCP. In addition, the Core is open to scientists at the National Cancer Institute. The Core instruments include a Carl Zeiss LSM 780 laser scanning confocal microscope, a Zeiss AxioScan Z1 fluorescent slide scanner, an Olympus VivaView Incubator Microscope, and a pair of Carl Zeiss Axio Observer epifluorescent microscopes. The Core provides access to cutting-edge technology and training on the Core's instruments as well as assistance with experimental design.
In addition to managing the LGCP Microscopy Core, Ross also conducts research in collaboration with Dr. Kathy Kelly Siebenlist on the role of CD97, an adhesion class GPCR, in tumor progression and metastasis.
Selected Recent Publications
- Oncotarget. 2016. [ Journal Article ]
- Cell Reports. 13: 2147–2158, 2015. [ Journal Article ]
- Cancer Res. 74: 4306-4317, 2014. [ Journal Article ]
- Oncogene. 32: 2726-2738, 2013. [ Journal Article ]
LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells.Cancer Res. 71: 7301-7311, 2011. [ Journal Article ]
Ross Lake has been a Biologist in the Microscopy Core Facility of the Laboratory of Genitourinary Cancer Pathogenesis in the Center for Cancer Research of the NCI for over 14 years. He has extensive experience in cell and molecular biology, immunohistochemistry, immunofluorescence, as well as in microscopy. Ross assumed responsibility for managing the LGCP Microscopy Core Facility in December 2014.