Sabrina Lusvarghi, Ph.D.
My research lies at the interface between chemistry and biology. I am mainly interested in using chemical and biochemical tools to answer biological and biophysical questions. I find the logic behind biology very intriguing, and trying to understand this is what motivates me as a scientist.
Our laboratory focuses on the study of ATP-binding cassette (ABC) drug transporters and their role in development of multidrug resistance (MDR) in cancers. My research focuses on the structural and biochemical characterization of P-glycoprotein (P-gp, ABCB1).
Selected Recent Publications
Binding site geometry and subdomain valency control effects of neutralizing lectins on HIV-1 viral particles.ACS Infect Dis. 2(11): 882-891, 2016. [ Journal Article ]
- Angew Chem Int Ed Engl. 54(19): 5603-8, 2015. [ Journal Article ]
- Nucleic Acids Res. 41(13): 6637-49, 2013. [ Journal Article ]
- J Am Chem Soc. 131(51): 18415-24, 2009.
Dr. Lusvarghi obtained her Ph.D. in chemistry at Carnegie Mellon University. She continued her research at the National Institutes of Health, using innovative tools to study nucleic acids, glycans and proteins. She is currently a staff scientist at the Laboratory of Cell Biology at NCI.