Orit Lavi, Ph.D.
The research program of the Integrative Cancer Dynamics Unit emphasizes an interdisciplinary theoretical approach to integrate the fields of mathematical oncology with data science, translating basic science into medicine using theories and methods from mathematics, physics, computer science and statistics. Our computational efforts will include the use/development of the theoretical frameworks necessary to answer a scientific question as part of the proposed program.
Our main goal is to develop a validated computational program that addresses tumor dynamics (initiation, growth, progression, evolution, interactions with the environment, etc.), drug resistance and treatment response to better guide therapeutic intervention in the clinic.
For complicated diseases, such as cancer, many of our excessive efforts to treat patients end in non-responding or relapsing patients, due to the complex dynamic behavior of such quickly evolving and adapting tumors. An integrated computational approach should be applied, including using complex and adaptive dynamical systems theories to describe the nonlinear biological phenomena involved. We will primarily be challenged with the integration of complex systems on different levels: cellular, cell population and whole body, with different data types describing: imaging, genotype, phenotype, drug response, patient response, etc.
Selected Recent Publications
Mathematical Modeling Reveals That Changes to Local Cell Density Dynamically Modulate Baseline Variations in Cell Growth and Drug Response.Cancer Res. 76(10): 2882-90, 2016. [ Journal Article ]
- Annu Rev Pharmacol Toxicol. 56: 85-102, 2016. [ Journal Article ]
- Cancer Res. 75(5): 808-12, 2015. [ Journal Article ]
- J Theor Biol. 367: 262-77, 2015. [ Journal Article ]
- BMC Syst Biol. 8: 88, 2014. [ Journal Article ]
Dr. Orit Lavi received her B.Sc., M.Sc. and Ph.D. in applied mathematics at Bar Ilan University, Israel. She completed her postdoctoral training at the Laboratory of Cell Biology, CCR, NCI. Her recent work has been focused on theoretical and empirical problems related to the dynamic processes involved in the development of drug resistance in cancer. Dr. Orit is currently a Staff Scientist and heads the Integrative Cancer Dynamics Unit, focusing on developing a validated computational program that addresses tumor dynamics, drug resistance and treatment response to guide therapeutic intervention in the clinic.
|Jeremiah Emidih||Postbaccalaureate Fellow (CRTA)|
|Sylvia Herrada||Postbaccalaureate Fellow (CRTA)|
|Vinod Rajapakse Ph.D.||Postdoctoral Fellow (CRTA)|