Erin Tran, Ph.D.
Dr. Tran studies the structural mechanisms used by pathogenesis and virulence factors during infection. Her work currently focuses on the determination of viral envelope glycoprotein structure in viruses such as HIV, influenza and Ebola using cryo-electron tomography. For more information, visit the High Resolution Microscopy website (https://electron.nci.nih.gov).
Areas of Expertise
1. Cryo-electron microscopy 2. Cryo-electron tomography 3. Host-pathogen interactions 4. Viral entry
Dr. Tran's research focuses on determining virus ultrastructure using state-of-the-art imaging techniques. Her current work uses cryo-electron tomography to obtain structures of viral surface glycoproteins, which are necessary for viral entry into cells. Cryo-electron tomography allows visualization of these proteins in a native state, still attached to the viral membrane. We aim to discover the structural changes that occur to these proteins upon cell entry or after binding to neutralizing antibodies. By determining the structures of these proteins, we hope to gain insights into the biological mechanisms necessary for infection by important human pathogens such as the HIV, influenza and Ebola viruses. For more information, visit the High Resolution Microscopy website (https://electron.nci.nih.gov).
Scientific Focus Areas:
Microbiology and Infectious Diseases, Structural Biology, Virology
Selected Recent Publications
Mapping of Ebolavirus Neutralization by Monoclonal Antibodies in the ZMapp Cocktail Using Cryo-Electron Tomography and Studies of Cellular Entry.J Virology. pii: JVI.00406-16, 2016. [ Journal Article ]
- mBio. 7: e00257-16, 2016. [ Journal Article ]
- J Virology. 88: 10958-10962, 2014. [ Journal Article ]
- Proc. Natl. Acad. Sci. USA. 110: 513-518, 2013. [ Journal Article ]
- PLoS Pathogens. 8: e1002797, 2012. [ Journal Article ]
Dr. Tran received a Bachelor of Science degree in Microbiology from the University of Kansas in 2001 and a Ph.D. in Microbiology from the Department of Bacteriology at the University of Wisconsin-Madison in 2008. She joined the Laboratory of Cell Biology at the National Cancer Institute in 2008 as a Post-doctoral fellow, then as a Research Fellow in 2013 and a Staff Scientist in 2016.