Maria I. Morasso, Ph.D.
The Morasso lab aims to understand the function of specific transcriptional regulators and pathways in molecular and cellular processes that contribute to epidermal differentiation and barrier formation, woud repair and the mechanisms underlying the pathologies of Ectodermal Dysplasias (EDs).
1) epidermis biology, 2) epidermal differentiation, 3) skin barrier formation, 4) Dlx3
The pathways that regulate stratified epidermis differentiation and the formation of a functional skin barrier have been a central topic of investigation in epidermis biology. Transcription is one of the most important regulatory mechanisms controlling the stepwise program of epidermal differentiation. Dr. Morasso's research efforts have focused on characterizing the regulation and function of Distal-less 3 (Dlx3) homeobox transcription factor, a member of the murine Dlx family.
Visit the Laboratory of Skin Biology for information on Dr. Morasso's current research at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).
Selected Recent Publications
SOX2 Epidermal Overexpression Promotes Cutaneous Wound Healing via Activation of EGFR/MEK/ERK Signaling Mediated by EGFR Ligands.J Invest Dermatol. [Epub ahead of print], 2019. [ Journal Article ]
Ectodermal dysplasias: Classification and organization by phenotype, genotype and molecular pathway.Am J Med Genet A. 179(3): 442-447, 2019. [ Journal Article ]
- Sci Transl Med. 10(451): eaap8798, 2018. [ Journal Article ]
A data mining paradigm for identifying key factors in biological processes using gene expression data.Sci Rep. 8(1): 9083, 2018. [ Journal Article ]
- J Invest Dermatol. 138(5): 1052-1061, 2018. [ Journal Article ]
Maria Morasso received a M.Sc. in Immunology and a Ph.D. in Biochemistry from the Instituto Venezolano de Investigaciones Cientificas, Venezuela. She did postdoctoral training in the Laboratory of Molecular Genetics in the National Institute of Child Health and Human Development (NICHD), NIH. In 2000, Dr. Morasso moved to NIAMS where she is currently a Senior Investigator and Chief of the Laboratory of Skin Biology. Dr. Morasso is also serving as an Adjunct Investigator at the Center for Cancer Research, NCI.
|Deepti Bajpai Ph.D.||Postdoctoral Fellow (Visiting), NIAMS|
|Michael A. Cross B.S.||Postbaccalaureate Fellow (IRTA), NIAMS|
|Daniela Grassni Ph.D.||Postdoctoral Fellow (Visiting), NIAMS|
|Kowser Hasneen||Biologist (Contr.), NIAMS|
|Spencer Mehdizadeh||Postbaccalaureate Fellow (IRTA), NIAMS|
|Subhashree Nayak Ph.D.||Postdoctoral Fellow (Visiting), NIAMS|
|Andrew Overmiller Ph.D.||Postdoctoral Fellow (IRTA), NIAMS|
|Andrew Sawaya Ph.D.||Postdoctoral Fellow (IRTA), NIAMS|