Houssein Abdul Sater, M.D.

Houssein Abdul Sater, M.D.
Assistant Research Physician

Dr. Sater is a translational physician scientist (hematologist/oncologist) with special interest in immune therapy of cancer. He leads the Genitourinary Malignancies Branch efforts at understanding the role of cancer immunotherapy on the tumor (immune and non-immune) micro-environment. Dr Sater is one of the few nationally recognized experts in tissue-based multiplex biomarker development and multispectral imaging. The Society of Immune Therapy of Cancer (SITC) chose him as one of 29 young leader investigators to tackle one of the major hurdles in immune therapy in a funded consortium effort (Sparkathon Timios Project). He also has an interest in demographics (gender, race, age, BMI) effect on immune therapy as a biomarker for better personalized medicine.

Areas of Expertise

1) immunotherapy of cancer, 2) immunopathology, 3) multispectal imaging, 4) clinical trial design, 5) biomarker development

Contact Info

Houssein Abdul Sater, M.D.
Center for Cancer Research
National Cancer Institute
Building 10, Room 6B12
Bethesda, MD 20892
Ph: 240-858-3384

Dr. Sater is a pan-tumor immuno-oncologist and research pathologist. His laboratory research is focused on understanding the role of cancer immunotherapy on the tumor (immune and non-immune) micro-environment with advanced multiplex assays and multispectral imaging. These advanced technologies enable the use of precious patient samples sparingly, multiplexing multiple antibodies on a single slide. He works closely with different CCR collaborators and the Laboratory of Tumor Immunology and Biology to translate preclinical findings into innovative clinical trials.

NIH Scientific Focus Areas:
Cancer Biology, Clinical Research, Computational Biology, Immunology

Selected Key Publications

  1. Clinical Trial Design in Immuno-Oncology.
    Houssein A. Sater, John Janik and Samir N. Khleif.
    In: Novel Designs of Early Phase Trials for Cancer Therapeutics. Academic Press 151-173, 2018. [ Book Chapter ]
  2. Gupta S, Hassan S, Bhatt VR, Abdul Sater H, and Dilawari A.
    Int J Gen Med. 7: 333–337, 2014. [ Journal Article ]
  3. Oncologist. 2019-0608: 2019. [ Journal Article ]
  4. Validity of 1% hormonal positivity cutoff by American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) guidelines at Georgia Cancer Center.
    Abdul Sater HT, Sadek RF, Zhang LF, Gopal A, Blaize JP, Yashar D, Patel R, Aribindi S, Patel HS, and Tang S-C.
    J Clin Oncol. 35: suppl. 1094, 2017. [ Journal Article ]
  5. Journal of Biological Chemistry 294.14 . 14: 5246-5260., 2019. [ Journal Article ]

Dr Sater is a nationally recognized expert in tumor immuno-pathology. He graduated from the Lebanese University School of Medicine in Lebanon with an M.D. in 2007 followed by a surgical pathology residency. Dr. Sater then completed his residency in internal medicine at Northshore LIJ system (Northwell Hospital, NY) in 2014, followed by a medical hematology/oncology fellowship at Augusta University, GA. In addition to training as a translational immunotherapist, he focused on understanding immune therapy effect on tumor immune and non-immune microenvironment in prostate, breast and lung cancer using advanced molecular and imaging techniques. Dr. Sater received several awards including a 2-year onco-pathology FOSFOM scholarship in Belgium and the SPARKATHON project award by the Society of Immune Therapy of Cancer. Dr. Sater has authored different journal articles and book chapters, and has given several invited presentations at national meetings.