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Kerstin  Heselmeyer-Haddad, Ph.D.

Kerstin Heselmeyer-Haddad, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Genetics Branch

RESEARCH SUMMARY

Dr. Heselmeyer-Haddad discovered that the majority of cervical carcinomas carry extra copies of the long arm of chromosome 3. She developed a diagnostic FISH test for the telomerase RNA component (TERC) on 3q which can differentiate low-grade from high-grade cervical disease with high sensitivity and specificity. The 3q test is now offered by several diagnostic labs. She recently developed a multiplex FISH assay that allows the simultaneous analysis of copy number changes of up to 10 tumor-specific genes on a single cell basis.

Areas of Expertise

Fluorescence In Situ Hybridization (FISH)
Cancer Genetics (cervix, Breast, Prostate, Colon-rectum)
3q Test
Multiplex FISH Single Cell Assay

Publications

Selected Key Publications

Single-cell resolved ploidy and chromosomal aberrations in nonalcoholic steatohepatitis-(NASH) induced hepatocellular carcinoma and its precursor lesions

Friemel J, Torres I, Brauneis E, Thörner T, Schäffer AA, Gertz EM, Grob T, Seidl K, Weber A, Ried T, Heselmeyer-Haddad K.
Sci. Rep. 12(1): 22622, 2022. [ Journal Article ]

Hard wiring of normal tissue-specific chromosome-wide gene expression levels is an additional factor driving cancer type-specific aneuploidies

Patkar S*, Heselmeyer-Haddad K*, Auslander N, Hirsch D, Camps J, Bronder D, Brown M, Chen WD, Lokanga R, Wangsa D, Wangsa D, Hu Y, Lischka A, Braun R, Emons G, Ghadimi BM, Gaedcke J, Grade M, Montagna C, Lazebnik Y, Difilippantonio MJ, Habermann JK, Auer G, Ruppin E, Ried T. (*joint first authors)
Genome Med. 13(1): 93, 2021. [ Journal Article ]

Single-cell genetic analysis of ductal carcinoma in situ and invasive breast cancer reveals enormous tumor heterogeneity yet conserved genomic imbalances and gain of MYC during progression

Heselmeyer-Haddad K, Berroa Garcia LY, Bradley A, Ortiz-Melendez C, Lee WJ, Christensen R, Prindiville SA, Calzone KA, Soballe PW, Hu Y, Chowdhury SA, Schwartz R, Schäffer AA, Ried T.
Am. J. Pathol. 181(5): 1807-22, 2012. [ Journal Article ]

Detection of genomic amplification of the human telomerase gene TERC, a potential marker for triage of women with HPV-positive, abnormal Pap smears

Andersson S, Sowjanya P, Wangsa D, Hjerpe A, Johansson B, Auer G, Gravitt PE, Larsson C, Wallin KL, Ried T, Heselmeyer-Haddad K.
Am. J. Pathol. 175: 1831-47, 2009. [ Journal Article ]

Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix

Heselmeyer K, Schröck E, du Manoir S, Blegen H, Shah K, Steinbeck R, Auer G, Ried T.
Proc. Natl. Acad. Sci. U.S.A. 93: 479-84, 1996. [ Journal Article ]