Jeremy Rose, M.S.
Jeremy Rose heads a transplantation immunology research facility that supports the clinical protocols of the Experimental Transplantation and Immunotherapy Branch through the collection of biospecimens, assistance with the preclinical development of adoptive T cell therapies, and the monitoring of engraftment, immune reconstitution, graft-versus-leukemia (GVL), and graft-versus-host disease (GVHD) following allogeneic transplantation.
1) immune reconstitution, 2) chronic graft-versus-host disease (cGVHD)
The Preclinical Development and Clinical Monitoring Facility provides translational support for adoptive T cell immunotherapies, including the development of standard operating procedures (SOPs) for the clinical manufacturing of innovative T cell products. The Facility provides centralized processing and secure storage for blood, marrow and tissue biospecimens collected under Branch clinical protocols, as well as the molecular and cellular analyses in support of research endpoints.
Selected Recent Publications
T Cells Genetically Modified to Express an Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor Cause Remissions of Poor-Prognosis Relapsed Multiple Myeloma.J Clin Oncol. 36: 2267-2280, 2018. [ Journal Article ]
Serial changes in lymphocyte subsets in patients with newly diagnosed high grade astrocytomas treated with standard radiation and temozolomide.J Neurooncol. 135: 343-351, 2017. [ Journal Article ]
- AAPS J. 19: 117-129, 2017. [ Journal Article ]
- Blood. 130: 2131-2145, 2017. [ Journal Article ]
- J Immunol. 197: 3490-3503, 2016. [ Journal Article ]
Jeremy Rose received his M.S. from Emory University before briefly joining the National Institute of Allergy and Infectious Diseases (NIAID) at NIH. There his research experience with HIV-1 and its accessory proteins began, spanning nearly a decade, prior to his arrival at the NCI. As part of the Preclinical Development and Clinical Monitoring Facility, he has supported the clinical protocols of the Experimental Transplantation and Immunology Branch and contributed to studies of allogeneic transplantation and adoptive T cell therapy.
|Zhouhong Cao||Biologist (Contr.)|
|Vicki S. Fellowes||Biologist|