Christian S. Hinrichs, M.D.

Christian S. Hinrichs, M.D.
Investigator
Lasker Clinical Research Scholar

Dr. Hinrichs researches immunotherapy for HPV+ cancers, which include cervical, oropharyngeal, anal, vulvar, vaginal, and penile malignancies. He has discovered personalized cellular and gene therapies for HPV+ cancers. His laboratory is studying why these treatments work in some patients and not in others and is using what is learned to innovate more effective therapies.

Areas of Expertise
1) immunotherapy, 2) cell therapy, 3) human papillomavirus, 4) cervical cancer, 5) oropharyngeal cancer, 6) anal cancer

Contact Info

Christian S. Hinrichs, M.D.
Center for Cancer Research
National Cancer Institute
Building 10, Room 4B04
Bethesda, MD 20892
Ph: 240-760-6059
Fax: 240-541-4541
hinrichs@mail.nih.gov

Cellular Therapy for Cancer

Dr. Hinrichs conducts basic and clinical research to discover and develop novel T cell therapies for the treatment of patients with cancer. This work includes a clinical trial of human papillomavirus (HPV)-targeted tumor-infiltrating T cells for patients with HPV+ cancers, which has demonstrated that this treatment can mediate complete regression of cervical cancer in some patients. Dr. Hinrichs' laboratory also has discovered genes for T cell receptors that target HPV, and his group is testing new gene therapy treatments based on these receptors for patients with advanced HPV+ tumors.

NIH Scientific Focus Areas:
Biomedical Engineering and Biophysics, Cancer Biology, Clinical Research, Immunology, Virology
View Dr. Hinrichs' PubMed Summary.

Selected Recent Publications

  1. Stevanović S, Draper LM, Langhan MM, Campbell RE, Kwong ML, Wunderlich JR, Dudley ME, Yang JC, Sherry RM, Kammula US, Restifo NP, Rosenberg SA, and Hinrichs CS
    J Clin Oncol. 33(14): 1543-50, 2015. [ Journal Article ]
  2. Draper LM, Kwong ML, Gros A, Stevanovic S, Tran E, Kerkar S, Raffeld M, Rosenberg SA, Hinrichs CS
    Clin Cancer Res. 21(19): 4431-9, 2015. [ Journal Article ]
  3. Tran E, Turcotte S, Gros A, Robbins, PF, Lu YC, Dudley ME, Wunderlich Jr, Somerville RP, Hogan K, Hinrichs CS, Parkhurst MR, Yang JC, and Rosenberg SA
    Science. 344(6184): 641-5, 2014. [ Journal Article ]
  4. Hinrichs CS and Rosenberg SA
    Immunol Rev. 257(1): 56-71, 2014. [ Journal Article ]
  5. Hinrichs CS and Restifo NP
    Nat Biotechnol. 31(11): 999-1008, 2013. [ Journal Article ]

Dr. Hinrichs received his B.A. and M.D. degrees from the combined 6-year program at the University of Missouri - Kansas City (UMKC). He trained in general surgery at UMKC and in surgical oncology at Roswell Park Cancer Institute. He then completed a surgical oncology and tumor immunology fellowship at the Surgery Branch of the National Cancer Institute (NCI). Subsequently he trained in internal medicine at George Washington University and in medical oncology at the Medical Oncology Branch of the NCI. Dr. Hinrichs conducts basic research and clinical research to develop T-cell therapies for cancers caused by human papillomaviruses.

Position Keywords Contact Name Contact E-mail Number of Positions
Postdoctoral Fellow- tumor immunology, CAR-T

tumor immunology, CAR-T, T cell, vaccine, checkpoint

Carylinda Serna

carylinda.serna@nih.gov

Multiple Positions Available
Administrative Assistant- Communication, Scheduling

organized, strong communication skills (oral/written)

Alicia Guevara

alicia.guevara@nih.gov

1
Name Position
John Davies Ph.D. Postdoctoral Fellow (CRTA)
Lindsey Draper M.D. Postdoctoral Fellow (CRTA)
Erin Ferraro Research Nurse Coordinator
Nikolaos Gkitsas Biologist (Contr)
Benjamin Jin Ph.D. Biologist (Contr)
Bridget Marcinkowski B.S. Postbaccalaureate Fellow (CRTA)
Rachael Mohn Patient Care Coordinator (Contr)
Nisha Nagarsheth Ph.D. Postdoctoral Fellow (CRTA)
Carylinda Serna Biologist (Contr)
Andrew Sinkoe Ph.D. Postdoctoral Fellow (CRTA)
Ling (Lisa) Zhang Ph.D. Biologist

For Researchers

Plasmids

Christian Hinrichs Lab Plasmids - Our lab has deposited plasmids at Addgene for distribution to the research community. Addgene is a nonprofit plasmid repository dedicated to improving life science research.

Protocols

SOP-D-001 - 293GP Retroviral Production

SOP-D-002 - Retroviral Transduction of Human T Cells