Sophie Wang, M.S.
As laboratory manager of the Endocrine Oncology Branch, my primary duties and responsibilities include calibrating and operating a variety of laboratory instruments as well as routine maintenance of lab equipment. I am also in charge of laboratory and common supplies orders, monitoring safety and bio-hazard standards within the lab, and performing aseptic techniques and biosafety procedures. In addition, I am responsible for the collection and storage of all clinical samples and maintenance of the LabMatrix database for all records.
Clinical and Genetic Studies in Familial Non-Medullary Thyroid Cancer (FNMTC)
This is a prospective study of individuals with or at risk for non-medullary thyroid cancer. Individuals will be studied over time within the context of their families in order to:
- quantify prospective risks of cancers in family members,
- establish the natural history of familial non-medullary thyroid cancer (FNMTC),
- define the spectrum of diseases within the families,
- identify precursor states,
- try to assess the contribution of genetic and environmental components of risk, and,
- develop effective screening strategies.
Our initial genomic analysis of human familial and sporadic cases of non-medullary thyroid cancer have identified several dysregulated genes which have important regulatory roles in thyroid cancer cell proliferation and cell cycle progression. We will further characterize the mechanism of gene expression regulation in FNMTC tumor samples and determine if these genes are modifier and/or susceptibility genes. Germline genetic studies to identify the susceptibility gene(s) for FNMTC are also underway using a variety of genetic approaches including linkage, association, copy number variation search, and exome/whole-genome sequencing to identify both common and rare genetic variants.
Selected Key Publications
- Neuro Oncol. 15(10): 1317-29, 2013. [ Journal Article ]
Maintaining serum response factor activity in the older equal to that of the young adult is associated with better cardiac response to isoproterenol stress.Basic Res Cardiol. 102(3): 233-44, 2006. [ Journal Article ]
Seprase promotes rapid tumor growth and increased microvessel density in a mouse model of human breast cancer.Cancer Res. 64(8): 2712-6, 2004. [ Journal Article ]
Glycosyl modification facilitates homo- and hetero-oligomerization of the serotonin transporter. A specific role for sialic acid residues.J Biol Chem. 278(45): 43991-4000, 2003. [ Journal Article ]
I received my Master's degree in organic chemistry from the YanBian University (YanBian, China) in 1988. I have been working in biomedical research laboratories for the past 13 years.
- Biologist, Endocrine Oncology Branch, CCR, Bethesda, MD (02/2015 – present)
- Biologist, Mouse Cancer Genetics Program, CCR, Frederick, MD (06/2010 – 01/2015)
- Research Specialist, Department of Genetics, University of North Carolina, Chapel Hill, NC (01/2008 – 05/2010)
- Research Assistant, Department of Molecular Biomedical Sciences, NCSU, Raleigh, NC (05/2006 – 12/2007)
- Research Assistant, Donald W. Reynolds Institute on Aging, UAMS, Little Rock, AR (11/2003 – 04/2006)
- Research Technologist II, Department of Pathology, UAMS, Little Rock, AR (01/2003 – 10/2003)
- Research Assistant, Department of Biochemistry, UAMS, Little Rock, AR (03/2002 – 12/2002)